8. pataloji hematopathology-6 Flashcards
Lymphopaslmatic lymphoma kimlerde görülür?
Older adults
Lymphopaslmatic lymphoma hangi katagoride yer alır
B hücreli non hodgkin lenfoma
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Richter transformation is rare
Lymphopaslmatic lymphoma;’nıon tümör hücreleri ne üretir?
IgM
Lymphopaslmatic lymphoma;’nıon tümör hücreleri nin ürettiği Igmnin fazla olması neye sebep olur?
hyperviscosity syndrom : Waldenström makroglobulinemy
Hyperviscosity syndromWununn semptomları nelerdir?
vision loss
neurological symtoms : headache , dizziness , hearing loss , stupor
Bleeding
Cryoglo ulinemy : macroglobulin precipitation in cold weather , Raynoudphenomenon , cold urticeria
In which situation is bone marrow failure seen?
mainly Aplastic anemia
: MDS, myelophitisic anemia , Pure red cell aplasia
Fanconi anemia is imp because=
: OR, DNA repair defect , young age , multiplecongenital anomalies spleen and kidney hypoplasia , bone anomalies )
What is Patogenesis of Aplastic anemia
Extrinscic : Immune supression
İntrinsic: bone marrow stem cell damage
Cytopenia related symptomas are?
Anemia: fatique , pallor , dyspnea
Trombocytopeni: bleeding disorders
Neutropenia: recurrent infections
No splenomegaly
What is Pure Red cell anemia :
only erythroid lineage is effected
what is Myelo phitizic anemia
bone marrow failure due to replacement of
hematopoietic cells by other mass lesion
What is Myelodisplastik syndrom
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Clinical features are related to cytopenia
Median age : 70
Clonal neoplasia of Hemapoietik stemm cell
Maturation defect
High risk of Transformation into AML
Prim ary or secondary (KT/RT
Erit hroid lineage: Ring sideroblast s : Fe loaded mitochondri may be seen as paranuclear granuls
Dohle Bodies can be seen in ?
- burn
- ınfection
- trauma
- neoplastic disease
- Chediak*higashi syndrome
Chronic myeloproliferati veneoplasias CMPN) are
İncreased proliferation in bone marrow
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1. Chronic myeloid leukemia
: increase of the production
myeloid ve lymphoid cell
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2. Polistemia vera
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3. Essential trombo cytemia
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4. Primary myelofibrosis
Ma sive splenomegaly cvould be caused by?
CML
Severe myelofibrosis
Kala azar
Malaria
Storage Disease
Talesemia Major
Portal vein abstruction
En sık Benign Neoplazi nedir?
Hemangiom
Kippel trenaunay sendromu ile görülür
Littoral Cell Angiom nedişr
Dalağa özgü bir tümör
En sık hematolenfoid dışı malign tümör
angisakroma
