8. pataloji hematopathology-6

Question 1

Lymphopaslmatic lymphoma kimlerde görülür?

Answer 1

Older adults

Question 2

Lymphopaslmatic lymphoma hangi katagoride yer alır

Answer 2

B hücreli non hodgkin lenfoma

*
Richter transformation is rare

Question 3

Lymphopaslmatic lymphoma;’nıon tümör hücreleri ne üretir?

Answer 3

IgM

Question 4

Lymphopaslmatic lymphoma;’nıon tümör hücreleri nin ürettiği Igmnin fazla olması neye sebep olur?

Answer 4

hyperviscosity syndrom : Waldenström makroglobulinemy

Question 5

Hyperviscosity syndromWununn semptomları nelerdir?

Answer 5

vision loss
neurological symtoms : headache , dizziness , hearing loss , stupor
Bleeding
Cryoglo ulinemy : macroglobulin precipitation in cold weather , Raynoudphenomenon , cold urticeria

Question 6

In which situation is bone marrow failure seen?

Answer 6

mainly Aplastic anemia

: MDS, myelophitisic anemia , Pure red cell aplasia

Question 7

Fanconi anemia is imp because=

Answer 7

: OR, DNA repair defect , young age , multiplecongenital anomalies spleen and kidney hypoplasia , bone anomalies )

Question 8

What is Patogenesis of Aplastic anemia

Answer 8

Extrinscic : Immune supression

İntrinsic: bone marrow stem cell damage

Question 9

Cytopenia related symptomas are?

Answer 9

Anemia: fatique , pallor , dyspnea

Trombocytopeni: bleeding disorders

Neutropenia: recurrent infections

No splenomegaly

Question 10

What is Pure Red cell anemia :

Answer 10

only erythroid lineage is effected

Question 11

what is Myelo phitizic anemia

Answer 11

bone marrow failure due to replacement of
hematopoietic cells by other mass lesion

Question 12

What is Myelodisplastik syndrom

*
Clinical features are related to cytopenia

Answer 12

Median age : 70

Clonal neoplasia of Hemapoietik stemm cell

Maturation defect

High risk of Transformation into AML

Prim ary or secondary (KT/RT

Erit hroid lineage: Ring sideroblast s : Fe loaded mitochondri may be seen as paranuclear granuls

Question 13

Dohle Bodies can be seen in ?

Answer 13

1. burn
2. ınfection
3. trauma
4. neoplastic disease
5. Chediak*higashi syndrome

Question 14

Chronic myeloproliferati veneoplasias CMPN) are

İncreased proliferation in bone marrow

Answer 14

*
1. Chronic myeloid leukemia
: increase of the production
myeloid ve lymphoid cell

*
2. Polistemia vera
*
3. Essential trombo cytemia
*
4. Primary myelofibrosis

Question 15

Ma sive splenomegaly cvould be caused by?

Answer 15

CML
Severe myelofibrosis
Kala azar
Malaria
Storage Disease
Talesemia Major
Portal vein abstruction

Question 16

En sık Benign Neoplazi nedir?

Answer 16

Hemangiom

Kippel trenaunay sendromu ile görülür

Question 17

Littoral Cell Angiom nedişr

Answer 17

Dalağa özgü bir tümör

Question 18

En sık hematolenfoid dışı malign tümör

Answer 18

angisakroma