7. pataloji Hematopatoloji 5

Question 1

Plasma cell neoplasies caused by?

Answer 1

• B cell proliferations: plasma cell differentiation

Question 2

Plasma cell neoplasies Allways monoclonal Ig or Ig fragment secretes: …. component

Sometimes only light chain
* Only heavy chain: very rare

Answer 2

M

Question 3

Soliter myeloma=plasmasitoma:

Answer 3

one mass in a bone/soft tissue
Bone: progression to MM in 10-20 years
Soft tissue: lung, oro/nasopharinx

Question 4

Smoldering multiple myeloma (SMM) nedir ?

Answer 4

asemptomatic,

M protein>3g/dl,

plasma cell ratio in bone marrow: %10-30,

75% of SM progress to MM in 15 years

Question 5

Multiple Myeloma kimlerde görülür?

Answer 5

50-60 yo

Question 6

multiple myeloma’nıjn özellikleri nelerdir?

Answer 6

Litic bone lesions:

Hipercalcemia:

Kidney failure: Bence Jones

Acquired immun deficiency (humoral

• Hiperviscosity syndrome

Exaggerated bone marrow infitrate

Question 7

About MM Heterogen molecular pathogenesis

good prognosis: …..

Bad prognosis

MYC rearrengement

NF-KB

IL-6:

RANKL:

WNT pathway

Answer 7

t(11;14), Cyclin D1

Del 17p, TP53

MYC rearrengement:
plasma cell leukemia in late phases: very agressive disease

NF-KB: B cell survival

IL-6: produced by tumor cells and stroma
important for treatment

RANKL:
activates osteoclasts  litic bone
lesions

WNT pathway: inhibits osteoblast function

Question 8

Lytic bone lesions seens at?

Answer 8

vertebrate, copsta, skull, pelvis, femur, clavicula,
scapula

• Patologic fractures

Punched out lytic lesions in Xray

Question 9

Most common death reason in MM?

Answer 9

infections , kidney failure

Question 10

Lymphoplasmacytic lymphoma seens in

Answer 10

Older ages

B-NHL

Tumor cells produces IgM

High level IgM causes Hyperviscosity syndrome