6. patalojii . Hematopathology-4

Question 1

What is the main diffrances betwen Hodgkin Lenfoma and NHL

Hodgkin Lymphoma is ?

Answer 1

Hodgkin Lymphoma is

Localized disease is common
If multiple LN is involvedthey are in the same region
Disseminates in order of Lymphatics
Mesenteric lymphatics and Waldeyer ring is rarely involved
Extranodal involvement is rare

Question 2

What is the main diffrances betwen Hodgkin Lenfoma and NHL
NHL is?

Answer 2

Multiple lymph node involvement is common

Disseminates unordered

Mesenteric lymphatics and Waldeyer ring involvement is common

Extranodal involvement is common

Question 3

Typically cervical and mediastinal lymph node caused by EBV is typicaly?

Answer 3

Hodgkin Lymphoma

Question 4

What is the two major sub tipes of Hodgkin Lymphoma

Answer 4

ClassicalHL

• Nodular Lymphocyte predominant HL(NLPHL)

Question 5

Reed Sternberg cells are hallmark for ?

Answer 5

Hodgkin Lenfoma

Question 6

Hodgkin Lenfoma’ hallmark cells are?

Answer 6

Reed Sternberg
B cell origin(%90), rarely Tcell origin

Question 7

For Nodular Lymphocyte predominant HL(NLPHL)

Germinal center …. cells with somatic mutations ongoing: CD….

Answer 7

B

CD20(+)

Question 8

For Classical Hodgk,n lenfoma CHL

• RSCs has lost…….

Mutations that cause stop codons in variable regions

Answer 8

B cell reseptors(Ig)

Question 9

Clinical fetures of CHL and NLPHL

For CHL

sites involved ……

Stage of diagnosis

Association with EBV

Agrasive ……

Answer 9

sites involved: Peripheral lymph nodes, Mediastinum, Abdomen

Stage opf diagnosis often 2 or 3

Curable

Question 10

What is RS immunphenotype?

Answer 10

CD30(+)
CD15(75-85 % +)
PAX5 (95% +)
CD20(20-40% +)
CD3 (-)

EBV ;LMP-1, EBER (+)