8. iç hastalıkları Interpretation of Hemostasis Tests

Question 1

What are the coagulation tests?

8

Answer 1

PT/INR

Aptt

Thronmine time (TT) or TCT

D-Dimer

Platlet function test

individual coagulation factor activities

mixing studies

factor inhibitor titer testing

Question 2

Cougulation screen INR ve D-Dimer için hangi renk kulanılır

Answer 2

Mavi

Question 3

FBC Blood Film Esr HBA1c İçin hangi renk kulanılır

Answer 3

mor

Question 4

What cause platelet aggregation?

GP

Answer 4

activation of GPIIb/IIIa

Question 5

Primary Hemostasiste ne olur

Answer 5

Vasoconstraction

Platlet Adhesion

Platlet activation

Platlet Aggregation: Plug formation

Question 6

Secondary Hemostasiste ne olur=

Answer 6

Formation of stable fibrin clote

Question 7

Damar hasarı factor 7 ye sebep olduktan sonra ne olur

Answer 7

7, 9’u dürter 10’u uyarır

Question 8

cougulation’un iç yolu nasıl çalışır

Answer 8

XII to factor XIIa

11 11a ya

9 9’a ya

Factor 8a, factor 9a nın kofaktörü gibi davranır ve beraber

ve devamında comman pathwaydeki factor 10u 10a ya çevirirler

Question 9

Common pathway of cougulation

Answer 9

factor X to factor Xa

conversion of prothrombin to thrombin by factor Xa. 5a hızlandırır

thronbin fibrinojenin fibrine dönüşümünü katalize eder

Question 10

PT INR nedir?

Answer 10

most commonly used coagulation test

INR = (patient PT/geometric mean normal PT)

measures the function of extrinsic and common coagulation pathways that include factors
VII, and factors II, V, and X, and fibrinogen

Question 11

causes of PT prolongation :

Answer 11

factor deficiencies :
factor VII , V, VII, and/or X, prothrombin, fibrinogen

vitamin K deficiency

liver disease

disseminated intravascular coagulation (

vitamin K antagonists including warfarin

Question 12

aPTT Nedir

Answer 12

mesurment of activation of intrinsic pathway

Question 13

causes of aPTT prolongation :

Answer 13

factor XII deficiency most common cause of isolated prolonged aPTT

deficiencies of factors XI, IX (hemophilia B), VIII (hemophilia A), X, II, and fibrinogen

vitamin K deficiency

DIC

liver disease

Question 14

vitamin K dependent clotting factors are?

Answer 14

FII, FVII, FIX, FX and protein C and protein S

Question 15

TT ve TCT ne işe yarar

Answer 15

measures the final step in the common coagulation pathway

conversion of fibrinogen to fibrin

detection of afibrinogenemia, hypofibrinogenemia and dysfibrinogenemia

detection of thrombin inhibitors

dysfibrinogenemia due to liver disease or hepatic malignancy

hypofibrinogenemia due to liver disease DIC

Question 16

D-Dimer nedir

Answer 16

fibrin degradation product

important in VTE, PTE and DIC

Question 17

conditions increase D dimer?

Answer 17

cancer

DIC

infection (COVID)

inflammatory conditions

recent surgery or trauma

liver disease

renal disease

atrial fibrillation

stroke

Question 18

What is 2. line test for primary hemostasis

Answer 18

Platlet Funciton Test

Question 19

the gold standard method for detecting abnormal platelet function is?

Answer 19

light transmission aggregometry

Question 20

bleeding time and platelet function analyzer (PFA) have been used as a?

Answer 20

screening test to look for platelet dysfunction

Question 21

Mixing studie nedir

Answer 21

mixing tests that correct abnormal prolongation of coagulation tests suggest factor deficiencies