5. iç hastalıkları Leukocyte Diseases

Question 1

Normal Range for the Leukocyte nedir?

Answer 1

4000 to 11,000
per mm3 of blood

Question 2

Leukocytosis nedir?

Answer 2

abnormal increase in WBC

Question 3

Causes of leukocytosis?

Answer 3

infection
inflammation
 Cancers of the bone marrow (leukemias)
bone marrow disorders (CML, MPN)
Certain medications (corticosteroids)

Question 4

Leukopenia nedir neden olur neye sebep olur?

Answer 4

acute viral infections

chemotherapy, radiation therapy

myelofibrosis, aplastic anemia

AIDS,
megaloblastic anemia,
myelodysplasia,
bone marrow failure,
acute leukemia

Question 5

Neutrophilin önemli özellikleri

Answer 5

en çok bulunan WBC

multi-lobed nucleus, consists of three to five lobes

• transparent fine granules in cytoplasm
• defend against bacterial or fungal infection

most common cell type seen in the early stages of acute inflammation

Question 6

Left Shift ne zaman olur? artık her neyse

Answer 6

immature neutrophils sayısının artması

Question 7

Leukemoid Reaction nedir?

Answer 7

an increase in the white blood cell count, which can mimic leukemia

secondary to malignant or inflammatory disease but not leukemia

sometimes in localized infections (abscess)

Question 8

Eosinophil nedir?

Answer 8

small granules in the cytoplasm, contain eosinophil peroxidase, ribonuclease, deoxyribonucleases, lipase, plasminogen, and major basic protein.

– responsible against parasites

• responsible for allergy and asthma

Question 9

most important causes of eosinophilia

Answer 9

allergies (asthma, hay fever, and hives)
parasitic infections

Question 10

Basophil nedir?

Answer 10

en nadir WBC
responsible for allergy and antigen response

release the chemical histamine

dark violet granules and bi- or tri-lobed nucleus

Question 11

Lymphocyte nedir?

Answer 11

18-42% of the WBC
büyük çekirdekli
lenf nodlarındaki ana hücre

more common in the lymphatic system than in blood

Question 12

T cells ne işe yarar

Answer 12

Thymus cells, involved in cell-mediated immunity

adaptive immune response

Question 13

B cells ne işe yarar

Answer 13

Bone marrow derived, secretion of antibodies, humoral immunity

adaptive immune response

Question 14

Natural Killer cells

Answer 14

NK cells, innate immune system, cell-mediated immunity

against tumoral and virally infected cells

Question 15

Monocyte nedir ne işe yarar?

Answer 15

largest WBC
kidney-shaped nucleus

macrophages in tissues

KANDAN dokuya geçer halleder döner

Question 16

Leukemia belirtileri

Answer 16

common signs are
lethargy, pale mucous membranes,
anorexia, weight loss,
fever,
frequent infections,
icterus,
abnormal bleeding such as petechiae.

Question 17

physical findings often of Leukemia

Answer 17

hepatosplenomegaly,
lymphadenopathy,
tonsillar enlargement.