2. genel cerrahi Splenic Diseases Flashcards
who did the first splenectomy?
Adriano Zaccavello
Spleen ne zaman oluşmaya basşlar
Gestational 12th
Spleen Derivate from?_
from mesoderm
Accessory Spleen seen in?
Accessory Spleen : %20 of population
imp things about Physical Examination of spleen
Traube
*
Kehr’s Sign
Hyposplenism?
Defective or absent spleen
Hypersplenism is?
*Defined as the presence of one or more
cytopenias ,
Splenomegaly is?
500g or greater in 15cm
* If greater than
1kg or 22cm in length, then its termed massive
splenomegaly.
Imaging Methods inAssessing Size andPathology
USG
*
Computerized Tomography
*
X ray
*
Magnetic Rezonans
*
Angiography
*
Tecnesium 99m Radiosintigraphy
Benign Hemathologic Diseases Of Spleen are?
Hereditary Spherocytosis
*
Enzymatic Defects
Pyruvate Kinase Enzyme Deficiency
G6PDH Enzyme Deficiency
Warm Type Autoimmun Hemolytic Anemia
Hemoglobinopathies
Sickle Cell Anemia , Talasemia
Platelet Disorders
*
ITP and TTP
Malignant Diseases of Spleen caused by white white blood cell disorders are
Hairy Cell Leucemia
*
Hodgkin’s Disease
*
Non Hodgkin Lymphoma
*
Chronic Lymphocytic Leucemia
Malignant Diseases of Spleen caused by Myeloproliferative Neoplasms are
Chronic Myeloid Leucemia
Acute Myeloid Leucemia
Chronic Myelomonocytic Leucemia
Essential Trombocytosis
Polisitemia Vera
Myelofibrosis
Storage Diseases and Infiltrative Disorders of spleen
Gaucher’s Disease
*
Niemann Pick Disease
*
Amyloidosis
*
Sarcoidosis
other imp disease of spleen
Splenic Artery Aneurism
*
Portal Hypertension
*
Felty Syndrome
*
Wandering Spleen
The Most Common İndications Of Splenectomy?
Splenic rupture (trauma)
The most common indications for elective splenectomy
Malignancy and hematologic autoimmune disorders ,
*
Idiopathic thrombocytopenic purpura (ITP)
o autoimmune hemolytic anemia
What is Hereditary spherocytosis (HS) is the most common type of hemolytic anemia for which splenectomy is indicated
Hereditary spherocytosis (HS) is the most common
What is most common glycolytic defect causing congenital non spherocytic hemolytic anemia
Pyruvate kinase (PK) deficiency
The most common red blood cell enzyme deficiency overall is …….. deficiency .
G6PD
Splenectomy is indicated for patients with excessive
transfusion requirements ,………
(>200 mL/kg per year)
The low platelet count stems from premature removal of platelets opsonized by ………………autoantibodies produced
in the spleen.
antiplatelet immunoglobulin G
Petechial hemorrhages in the lower extremities are the most common presenting sign of
Thrombotic Thrombocytopenic Purpura
What happens at Thrombotic Thrombocytopenic Purpura
Abnormal platelet clumping occurs in arterioles and
capillaries, reducing the lumen of these vessels and
predisposing the patient to microvascular thrombotic
episodes.
HCL is characterized by ……
splenomegaly, pancytopenia, and large numbers of abnormal lymphocytes in the bone marrow.
