3. pataloji HEMATOPATHOLOGY-1

Question 1

Neoplastic proliferations of White cells are?

Answer 1

• Lymphoid tumors:
• Myeloid tumors
  ,
• Langerhans cell histiocytosis

Question 2

• Lymphoid tumors are?

Answer 2

B, T and NK cell tumors

Question 3

• Myeloid tumors are?

Answer 3

Acut Myeloid leukemias
Myelodisplastiic Syndrom
Myeloproliferative neoplasias

Question 4

Acut leukemia frequency is increased in?

Answer 4

Bloom syndrom
Fankoni anemia
Ataksia Telanjiectasia

Question 5

Childhood leukemias frequency is increased in?

Answer 5

Down syndrom and Type 1 Neurofibromatosis

Question 6

Adult T cell Leukemia/lymphoma is caused by …. virus

Answer 6

HTLV-1

Question 7

Burkitt lymphoma, Hodgkin Lymphoma, some NK cell lymphomas, in the T cell
immunodeficiency related B cell lymphomas

Caused by …. virus

Answer 7

EBV

Question 8

Efusion lymphoma cauesed by

Answer 8

• HHV8:

Question 9

Gastric B-NHL caused by

Answer 9

H.pylori

Question 10

Intestinal T-NHL cauesd by

Answer 10

Gluten sensitive enteropathy

Question 11

Breast implant can cause

Answer 11

T-NHL

Question 12

CT-RT can be caused by?

Answer 12

İatrogenic:

Question 13

…………. spread with an order but …. doesnt

Answer 13

Hodgkin lymphoma
NHL

Question 14

Akut lenfoblastik lösemi ALL is the most common cancer in

Answer 14

childhood

Question 15

the most common cancer in childhood is

Answer 15

Akut lenfoblastik lösemi ALL

Question 16

Clinical features

Anemia:

Answer 16

weakness

Question 17

Clinical features

Neutropenia:

Answer 17

fever, susceptibility to infections

Question 18

Clinical features

Trombocytopenia:

Answer 18

petechiae, purpura, mucosal bleedings, bleeding gums

Question 19

Clinical features

Question 20

Clinical features

Bone pains, bone sensitivity:

Answer 20

more common in ALL

Question 21

Clinical features

Leukemic spread

disseminated lymphadenopathy, hepatomegaly, splenomegaly

Answer 21

(more common in
ALL)

Question 22

Clinical features

Meningeal/CNS spread: headache, nausea/vomiting, paralysis

Answer 22

(more common in ALL)

Question 23

Clinical features

Testicular spread:

Answer 23

(more common in ALL)

Question 24

B and T cell tumors Immunophenotype

Answer 24

TDT

CD10, CD34

CD19, CD20, CD22, PAX5: B

CD2, CD3, CD5, CD7: T

Question 25

Bad prognosis of B and T Cell tumors

Answer 25

Yaş: <2, >10
MLL gene mutation
WBC>100.000

Question 26

Good prognosis

Answer 26

Age: 2-10 yo

2. WBC<100.000
3. Hyperdiploidy
4. Trizomy 4, 7, 10
5. t(12;21)