6. iç hastalıkları platlet disease Flashcards
which protein does Platelet contains?
Which factors
Which chemotactic agents
glycoproteins (GPIb/IX/V; GPVI; GPIIb/IIIa),
factor 5, 7
fibrinogen, fibronectin
platelet-derived growth factor
chemotactic agents
ADP,
calcium, and serotonin
what does Thrombocytopenia means?
low levels of platlet
caused by failure of the bone marrow, increased destruction of platelets
chemotherapy, aplastic anemia, leukemias, drugs could cause too
Immune Thrombocytopenia (ITP)
Thrombotic microangiopathies (TMA)
Thrombotic thrombocytopenic purpura (TTP)
Hemolytic uremic syndrome (HUS)
Can cause:?
can cause increased destruction of platelets
what is Pseudothrombocytopenia?
low platelet count caused by the agglutination of platelets
what can cause Pseudothrombocytopenia=
typically EDTA (ethylenediaminetetraacetic acid )
recheck with citrate anticoagulated blood sample
which container contains HEPARİN
GREEN
Which container can be used to study cougulation factor of blood
sodium citrate
BLUE
Which container is for Glucose est…
Sodium Floride
GREY
Any color makes them hungrey
What is ITP
characterized by low platelet count in the absence of other causes
Such as increased platelet destruction
autoantibodies
What is Thrombocytosis
elevated platelet concentration FAZLA PIHTI
Chronic myeloid leukemia (CML)
Polycythemia vera (PV)
Primary myelofibrosis (PMF)
Essential thrombocythemia (ET)
Can cause?
Thrombocytosis
which diseases and drugs can cause Thrombocyte Dysfunction
Von Willebrand disease
Glanzmann disease
- Bernard-Soulier syndrome
aspirin and other antiplatelet drugs
Platelet concentration in the blood is measured by CBC
What is most common inherited platelet-related disorder
- Von Willebrand disease
Drugs that prevent platelet function?
1
2
3
4
5
6
Aspirin
Cilostazol
Clopidogrel
Prasugrel
Ticagrelor
Ticlopidine
