4. pataloji Hematopathology 2

Question 1

Clinical features of * Acute Myeloblastic leukemia is related with ……….

Answer 1

bone marrow replacement by tumor cells

Anemia
Trombocytopenia
Neutropenia

Question 2

Acute Myeloblastic leukemia

All ages may be effected but peak incidence is?

Answer 2

60 yo

If there is no blast in the periphery: aleukemic
leukemia

Question 3

AML with t(15;17): ……… Can be treated via ATRA

Answer 3

PML-RARA fusion protein

Question 4

AML with t(15;17): PML-RARA fusion protein Can be treated via …..

Answer 4

ATRA

Question 5

AML with t(15;17): PML-RARA fusion protein Can be treated via ATRA

t(15;17) and …. mutations are frequently seen together

Answer 5

FLT3

Question 6

Morphologically differentiation of AML/ALL

Answer 6

AML: MPO, SB (+)
Monoblast: NSE(+)
Stem cell: CD33
Myeloid related: CD13, CD14, CD15, CD64, CD117

Question 7

What is the Cytogenetic of AML

Answer 7

t(8;21), inv(16), t(15,17)

Question 8

AML klinik
t(15;17) caueses?

Answer 8

bleeding

Question 9

AML klinik

Infections of aml

Answer 9

oral cavity, lungs, skin, kidneys

with opportunisic pathogens: fungus, pseudomonas

Question 11

AML klinik

Monocytic differentiation:

Answer 11

skin/gingival involvement

Question 12

AML klinik

CNS spread is less seen than

Answer 12

ALL

Question 13

AML klinik

Mass presentation:

Answer 13

myeloblastom chloroma; granulocytic

monocytic sarcoma; extramedullary myeloid tumour, myeloid sarcoma