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Pathology finish > 65. Epithelial skin and adnexal tumors > Flashcards

65. Epithelial skin and adnexal tumors Flashcards

1
Q
  1. Epithelial skin and adnexal tumors

types of benign tumor (3)

A

seborrheic keratosis
actinic keratosis
keratoacanthoma

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2
Q
  1. Epithelial skin and adnexal tumors

definition of seborrheic keratosis

A

benign squamous proliferation of keratinocyte

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3
Q
  1. Epithelial skin and adnexal tumors

gross, microscopic morphology of seborrheic keratosis (4)

A

raised, discolored plaque (tan, brown or black)
hyperkeratosis
acanthosis
keratin pseudocyst

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4
Q
  1. Epithelial skin and adnexal tumors

special characteristics of seborrheic keratosis

A

Leser-Tralet sign : sudden onset of multiple seborrheic keratosis
- suggest underlying GI carcinoma

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5
Q
  1. Epithelial skin and adnexal tumors

etiology, malignancy of actinic keratosis

A
  • by chronic exposure to sunlight, cause p53 mutation

- pre-malignant lesion of squamous cell carcinoma

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6
Q
  1. Epithelial skin and adnexal tumors

morphology of actinic keratosis

A

hyperkeratosis

scaly plaque

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7
Q
  1. Epithelial skin and adnexal tumors

types of carcinoma of skin (2)

A

basal cell carcinoma

squamous cell carcinoma

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8
Q
  1. Epithelial skin and adnexal tumors

etiology of basal cell carcinoma (3)

A

chronic sun exposure
UVB induced DNA damage
immunosuppression

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9
Q
  1. Epithelial skin and adnexal tumors

gross morphology of basal cell carcinoma

A

elevated nodule with central ulcerated crater

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10
Q
  1. Epithelial skin and adnexal tumors

microscopic morphology of basal cell carcinoma (2)

A

palisading of basal cell nodule

telangiectasis of vessel (pink pearl like papule)

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11
Q
  1. Epithelial skin and adnexal tumors

etiology of squamous cell carcinoma (4)

A

sun exposure
UVB induced DNA damage
immunosuppression
chronic inflammation

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12
Q
  1. Epithelial skin and adnexal tumors

location, microscopic & gross morphology of squamous cell carcinoma

A

usually on face
keratin pearl
ulcerated, nodular mass

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13
Q
  1. Epithelial skin and adnexal tumors

precancerous lesion of squamous cell carcinoma

A

actinic keratosis

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14
Q
  1. Epithelial skin and adnexal tumors

gross & microscopic morphology of keratoacanthoma (3)

A

sharply circumscribed
center crater filled with keratin
well differentiated keratinized squamous epithelium

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15
Q
  1. Epithelial skin and adnexal tumors

growth characteristic of keratoacanthoma

A

rapidly growing

regress spontaneously

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Pathology finish (30 decks)

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