58. Non-neoplastic diseases of the thyroid gland Flashcards
58-1. hyperthyroidism
etiology of hyperthyroidism (3)
Graves disease
multinodular goiter
hyperfunctioning adenoma
58-1. hyperthyroidism
etiology of graves disease
autoimmune disease stimulate TSH receptor
58-1. hyperthyroidism
clinical manifestation of graves disease (3)
exophthalmos
pretibial myxedema
thyrotoxicosis
58-1. hyperthyroidism
gross morphology of graves disease
diffuse enlargement of thyroid
58-1. hyperthyroidism
laboratory finding, radioactivity of graves disease
decreased serum TSH
increased serum T3, T4
increased iodine uptake (hot nodule)
58-1. hyperthyroidism
etiology of multinoduler goiter
iodine deficiency
- endemic : iodine deficient soil
- sporadic : mostly in puberty female
58-2. hypothyroidism
etiology of hypothyroidism
hashimoto thyroiditis
iodine deficiency
58-2. hypothyroidism
clinical manifestation of hypothyroidism
cretinism
myxedema
58-2. hypothyroidism
epidemiology, etiology of cretinism (3)
neonate, infant
maternal hypothyroidism, thyroid agenesis, maternal iodine deficiency
58-2. hypothyroidism
clinical manifestation of cretinism
skeletal system impairment
CNS development impairment : mental retardation
58-2. hypothyroidism
epidemiology, etiology of myxedema (2)
older children, adult
iodine deficiency, hashimoto thyroiditis
58-2. hypothyroidism
clinical manifestation of myxedema (9)
accumulation of GAG in soft tissue slowed mental activity muscle weakness cold intolerance fatigue weight gain bradycardia hypercholesterolemia constipation
58-3. thyroiditis
types of thyroiditis
Hashimoto thyroiditis De quervain (subacute granulomatous) thyroiditis Riedel fibrosing thyroiditis
58-3. thyroiditis
etiology of hashimoto thyroiditis
autoimmune destruction of thyroid, HLA-DR5
58-3. thyroiditis
gross morphology of hashimoto thyroiditis
painless enlargement of thyroid, symmetric, diffuse