61. Multiple endocrine neoplasia (MEN) syndrome

Question 1

61. Multiple endocrine neoplasia (MEN) syndrome

definition of MEN syndrome

Answer 1

groups of inherited disease, resulting in proliferative lesions of multiple organs

Question 2

61. Multiple endocrine neoplasia (MEN) syndrome

characteristics of MEN syndrome (4)

Answer 2

onset of younger age
multiple organ, multifocal proliferation
proceded by hyperplasia
aggressive and high recurrent

Question 3

61. Multiple endocrine neoplasia (MEN) syndrome

genetic characteristics of MEN-1 syndrome

Answer 3

autosomal dominant, 11q13 mutation

Question 4

61. Multiple endocrine neoplasia (MEN) syndrome

associated organ of MEN-1 syndrome

Answer 4

3P
parathyroid gland : hyperparathyroidism
pancreas : pancreatic islet carcinoma
pituitary gland : prolactin secreting adenoma, GH secreting adenoma

Question 5

61. Multiple endocrine neoplasia (MEN) syndrome

genetic characteristics of MEN-2 syndrome

Answer 5

autosomal dominant, 10q1.2 mutation (RET proto-oncogene)

Question 6

61. Multiple endocrine neoplasia (MEN) syndrome

associated organ of MEN-1A syndrome

Answer 6

2P, 1M
parathyroid gland : hyperparathyroidism
adrenal medulla : pheochromocytoma
thyroid gland : medullary carcinoma

Question 7

61. Multiple endocrine neoplasia (MEN) syndrome

associated organs of MEN-2B syndrome

Answer 7

1P, 2M
adrenal medulla : pheochromocytoma
thyroid gland : medullary carcinoma
marfanoid habitus