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Pathology finish > 64. Inflammatory skin diseases and major morphologic types > Flashcards

64. Inflammatory skin diseases and major morphologic types Flashcards

1
Q

64-1. Inflammatory skin diseases (acute and chronic dermatitis, infective dermatitis)

types of acute dermatitis (4)

A

eczematous dermatitis
contact dermatitis
erythema multiforme
acne vulgaris

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2
Q

64-1. Inflammatory skin diseases (acute and chronic dermatitis, infective dermatitis)

pathomechanism of eczematous dermatitis

A 
type 1 (immediate) hypersensitivity
allergic, atopic, photoeczematous allergen, drug
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3
Q

64-1. Inflammatory skin diseases (acute and chronic dermatitis, infective dermatitis)

clinical manifestation of eczematous dermatitis

A

pruritic, erythematous, oozing rash with vesicle & edema

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4
Q

64-1. Inflammatory skin diseases (acute and chronic dermatitis, infective dermatitis)

pathomechanism of contact dermatitis

A 
type 4 (cell mediated) hypersensitivity
by allergens (ivy poison, nickel, chemical, drug)
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5
Q

64-1. Inflammatory skin diseases (acute and chronic dermatitis, infective dermatitis)

clinical manifestation of contact dermatitis

A

pruritic, erythematous, oozing rash with vesicle & edema

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6
Q

64-1. Inflammatory skin diseases (acute and chronic dermatitis, infective dermatitis)

pathomechanism of erythema multiforme (2)

A

HSV, mycoplasma, fungal infection

Steven johnson syndrome

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7
Q

64-1. Inflammatory skin diseases (acute and chronic dermatitis, infective dermatitis)

clinical manifestation of erythema multiforme

A

targetoid rash and bullae

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8
Q

64-1. Inflammatory skin diseases (acute and chronic dermatitis, infective dermatitis)

pathomechanism of acne vulgaris

A

hormone associated : increased sebum -> block sebacious gland -> inflammation
propionibacterium acne infection

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9
Q

64-1. Inflammatory skin diseases (acute and chronic dermatitis, infective dermatitis)

types of chronic dermatitis (2)

A

psoriasis

lichen planus

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10
Q

64-1. Inflammatory skin diseases (acute and chronic dermatitis, infective dermatitis)

pathogenesis of psoriasis

A

autoimmune by HLA-C or trauma

cause excessive keratinocyte proliferation

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11
Q

64-1. Inflammatory skin diseases (acute and chronic dermatitis, infective dermatitis)

clinical manifestation of psoriasis (4)

A

acanthosis : epidermal hyperplasia
parakeratosis : nuclei in superficial keratinocyte
munro microabscess : neutrophil infiltration
auspitz sign : pinpoint bleeding

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12
Q

64-1. Inflammatory skin diseases (acute and chronic dermatitis, infective dermatitis)

gross morphology of psoriasis

A

well demarked salmon color plaque with silvery scale

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13
Q

64-1. Inflammatory skin diseases (acute and chronic dermatitis, infective dermatitis)

characteristics of lichen planus

A

4P

pruritic, planar, polygonal, purple papule

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14
Q

64-1. Inflammatory skin diseases (acute and chronic dermatitis, infective dermatitis)

microscopic characterictics of lichen planus

A

‘saw tooth’ like appearance of dermal-epidermal junction

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15
Q

64-2. Blistering skin disorders

types of blistering skin disorder (3)

A

pemphigus
bullous pemphigoid
dermatitis herpetiformis

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16
Q

64-2. Blistering skin disorders

etiology of pemphigus

A

IgG mediated autoimmune disease, against desmosome

17
Q

64-2. Blistering skin disorders

affecting location of pemphigus

A

stratum spinosum of skin & oral mucosa

18
Q

64-2. Blistering skin disorders

clinical manifestation of pemphigus

A

acantholysis of stratum spinosum, form suprebasal blister

easily rupture bullae, cause shallow erosion

19
Q

64-2. Blistering skin disorders

etiology of bullous pemphigoid

A

IgG mediated autoimmune disease, against hemidesmosome

20
Q

64-2. Blistering skin disorders

clinical manifestation of bullous pemphigoid

A

acantholysis of stratum basale, form blister of skin (spare mucosa)
not easily rupturable

21
Q

64-2. Blistering skin disorders

etiology of dermatitis herpetiformis

A

IgA mediated autoimmune deposition on dermal papillae

22
Q

64-2. Blistering skin disorders

clinical manifestation of dermatitis herpetiformis

A

grouped pruritic vesicle and bullae (herpetiform)

23
Q

64-2. Blistering skin disorders

related disease with dermatitis herpetiformis

A

celiac disease (gluten sensitive)

Pathology finish (30 decks)

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