4_4FishOil Flashcards

1
Q

What are the 3 main omega-3’s?

A

DHA, EPA, ALA

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2
Q

DHA

A

docosahexanoic acid

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3
Q

EPA

A

eicosapentanoic acid

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4
Q

ALA

A

alpha-linoleic acid

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5
Q

What is the optimal ratio of omega6 : omega3?

A

3:01

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6
Q

What are the benefits of omega 6’s?

A

only good for substitution for saturated fat

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7
Q

What are the benefits of omega9s?

A

good for substitution for saturated fat

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8
Q

What is an omega9?

A

oleic acid

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9
Q

What are the sources of omega3s?

A

1) fish (best), 2) fish oils; 3) plant sources

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10
Q

What is the recommended intake of fish per week?

A

two 3 oz servings q week

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11
Q

Why are fish the best sources of omega3s?

A

natural TGs and other nutrients

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12
Q

What fish should be avoided?

A

1) white tuna (Hg); 2) farmed salmon (PCBs)

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13
Q

What are the 3 general forms of omega3s in fish oils?

A

natural TGs, ethyl esters, re-esterified TGs

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14
Q

Which form of omega3 is best absorbed?

A

natural

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15
Q

What are the types of fish oils in supplements?

A

algal, krill, calamari

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16
Q

considerations for algal oil?

A

more DHA, expensive, low in contaminants, good for vegetarians

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17
Q

considerations for krill oil

A

no fishy taste, expensive, phospholipids increase F by stimulating bile

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18
Q

considerations for calamari oil

A

more DHA, low in contaminants

19
Q

What are the plant sources of omega3s?

A

1) flaxseed, 2) walnuts, 3) green leafy veggies, 4) chia, 5) hemp oil, 6) black currant

20
Q

For what conditions may flaxseed be PE?

A

ADHD, dry eye, adjunct for bipolar therapy

21
Q

What fats are contained in plant sources?

A

more ALA and other polyunsaturated fats; little converted to DHA/EPA

22
Q

How does ALA differ from EPA/DHA in terms of health benefit?

A

ALA doesn’t decrease CVD risk

23
Q

Describe the content of ALA in flaxseed?

A

55%; most in the oil as opposed to the seed

24
Q

What substances does the flaxseed seed contain as opposed to the oil?

A

phytoestrogens

25
Q

What are the proposed benefits of phytoestrogens?

A

1) prevent cancer, 2) decrease cholesterol, 3) improve menopausal symptoms; 4) decrease BP

26
Q

Describe the CV benefits of EPA/DHA.

A

1) hi-dose can decrease TGs if very high; 2) potential benefit if no fish intake and no CV meds

27
Q

What do EPA/DHA NOT do regarding CVD?

A

benefit heart disease, MI, or stroke

28
Q

What are general uses of EPA/DHA?

A

Arthritis (RA), cancer, age-related macular degneration, biopolar/psychosis; IE for Alzheimers

29
Q

How is fish oil dosed?

A

300-500 mg/day of DHA/EPA with fatty meals

30
Q

What is the FDA’s recommended limit on DHA/EPA?

A

3g/day (2 g/day from supplements)

31
Q

What are the ADRs of DHA/EPA at > 3 mg/day?

A

1) anticoag interaction to increase bleeding; 2) burping; 3) diarrhea; 4) vitamin A/D toxicity

32
Q

What are the ADRs of DHA/EPA at > 20 mg/day?

A

immunosuppression

33
Q

What dose of EPA/DHA is needed to lower TGs?

A

1-6 g/day

34
Q

Who may be allergic to fish oils?

A

those allergic to fish

35
Q

How should EPA/DHA be stored?

A

away from light and heat (best in fridge - if cloudy, shake before use)

36
Q

What fish sources are generally higher in mecury?

A

large, longer-lived fish (fish oils generally Hg-free)

37
Q

What populations should be LIMITED to 6 oz of fish per week?

A

pregnant, nursing, young kid

38
Q

What fish sources are generally higher in PCBs?

A

all fish have more than supplements

39
Q

What did the 2013 SELECT trial find?

A

correlation to prostate cancer

40
Q

What did the 2012 OPERA and 2013 FORWARD trials find?

A

no prevention of Afib

41
Q

What are fish oil administration recommendation for kids?

A

1) flavor liquids with oil-based flavorings; 2) avoid cod liver oil (high in vit. A); 3) bedtime admin may increase tolerability

42
Q

What omega3 has been added to infant formulas?

A

DHA

43
Q

What are the proposed benefits of DHA in infants?

A

may benefit premature babies most - 1) accrues in brain, so cognitive; 2) found also in retina