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Bacte Lec [Midterms] > 2.9.2.1 Salmonella Enterica > Flashcards

2.9.2.1 Salmonella Enterica Flashcards

1
Q

What are the Salmonella enterica subspecie?

A

typhi
paratyphi
choleraesius

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2
Q

What are the Virulence factors of Salmonella enterica?

A

Fimbriae

Enterotoxin (Similar to ETEC) = (Diarrhea / gastroenteritis)

Transverse intestinal mucosa

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3
Q

Primary antigenic structures used in serologic grouping of Salmonellae

A

O and H

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4
Q

O antigen of Salmonellae indicates?

A

Active infection

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5
Q

H antigen of Salmonellae indicates?

A

Post vaccination or previous infection

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6
Q

What is type of K antigen is in Salmonella?

A

Vi antigen or Virulent antigen

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7
Q

K antigen of salmonella indicates?

A

Patient is a carrier or asymptomatic

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8
Q

What are clinical infections of Salmonella enterica?

A

Acute gastroenteritis (Food poisoning)
Enteric fever
Typhoid fever

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9
Q

What is the infective dose of Salmonella enterica in Acute gastroenteritis?

A

10^6 CFU

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10
Q

What will happen if the infective dose in greater than 10^6?

A

Severe infection

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11
Q

Salmonellae that is responsible for a nationwide outbreak to Peanut butter-containing products

A

S. typhimurium

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12
Q

Salmonella is usually present in what products?

A

Poultry
Egg
Milk

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13
Q

Salmonella enterica is highly susceptible to the patients with?

A

Sickle cell disease
Ulcerative colitis and malignancy

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14
Q

S. enterica causes _________ type of diarrhea

A

Systemic

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15
Q

What individual is more prone to severe complications that may affect the bone marrow?

A

Immunocompromised patietns

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16
Q

Clinical features include prolonged fever, bacteremia, involvement of RES and dissemination to multiple organs?

Enters blood stream then organs

Recurrent invasion

A

Enteric fever

17
Q

Severe type of enteric fever caused by Salmonella typhi

A

Typhoid fever

18
Q

Typhoid fever is isolated in what specimen?

A

Blood (Wk 1-2)
Stool (Wk 2-3)
Urine (Wk 3-4)

19
Q

Typhoid fever can be detected when the patient has previous infection through?

A

Vi or K antigen

20
Q

What is the Incubation time of Salmonella enterica subspp. typhi?

A

9-14 days

21
Q

What is the 1st week of infection for Typhoid fever?

A

Bacteremia
Ingestion in the mouth then enter blood stream

22
Q

In the 2nd week of typhoid fever, where does the S. typhi penetrate to what system?

A

Reticuloendothelial system

23
Q

What are the organs of Reticuloendothelial system?

A

Liver (Foci of necrosis)
Spleen
Bone marrow

24
Q

What happen if S. typhi infects spleen?

A

Splenomegaly

25
Q

What happens in 2nd and 3rd week of S. typhi

A

Involves in different organs

26
Q

Process in 2nd to third week of S. typhi

A

Leave from RES then goes back to Lymphatic circulation then invades GIT

27
Q

What happens if S. typhi invades GIT?

A

causes rash around the umbilical cord called rose spot

Intestinal bleeding / Ulceration (Peyer’s patches)

28
Q

What happens in 3rd week of infection of Salmonella typhi?

A

Goes back to intestine

29
Q

What happens in 4th week of infection of Salmonella typhi?

A

Goes to gallbladder which may cause severe infection or in Carrier state

Chronic State and infection and may involve other parts of the body

30
Q

What is being collected on the 1st week of S. typhi infection?

A

Blood

31
Q

What is being collected on the 2nd-3rd week of S. typhi infection?

A

Stool

32
Q

What is being collected on the 3rd - 4th week of S. typhi infection?

A

Urine

33
Q

When will the patient with S. typi be in a Carrier state?

A

4th week

34
Q

Other enteric fevers may caused by?

A

paratyphi
choleraesuis

35
Q

Prolonged fever with intermittent bacteremia

A

Nontyphoid bacteremia

36
Q

Nontyphoid bacteremia is associated with?

A

typhimurium
paratyphi
choleraesuisy

37
Q

What is the indication for 3rd to 4th week for Typhoid fever?

A

Rose spots

Bacte Lec [Midterms] (93 decks)

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