2.9.2.1 Salmonella Enterica Flashcards
What are the Salmonella enterica subspecie?
typhi
paratyphi
choleraesius
What are the Virulence factors of Salmonella enterica?
Fimbriae
Enterotoxin (Similar to ETEC) = (Diarrhea / gastroenteritis)
Transverse intestinal mucosa
Primary antigenic structures used in serologic grouping of Salmonellae
O and H
O antigen of Salmonellae indicates?
Active infection
H antigen of Salmonellae indicates?
Post vaccination or previous infection
What is type of K antigen is in Salmonella?
Vi antigen or Virulent antigen
K antigen of salmonella indicates?
Patient is a carrier or asymptomatic
What are clinical infections of Salmonella enterica?
Acute gastroenteritis (Food poisoning)
Enteric fever
Typhoid fever
What is the infective dose of Salmonella enterica in Acute gastroenteritis?
10^6 CFU
What will happen if the infective dose in greater than 10^6?
Severe infection
Salmonellae that is responsible for a nationwide outbreak to Peanut butter-containing products
S. typhimurium
Salmonella is usually present in what products?
Poultry
Egg
Milk
Salmonella enterica is highly susceptible to the patients with?
Sickle cell disease
Ulcerative colitis and malignancy
S. enterica causes _________ type of diarrhea
Systemic
What individual is more prone to severe complications that may affect the bone marrow?
Immunocompromised patietns
Clinical features include prolonged fever, bacteremia, involvement of RES and dissemination to multiple organs?
Enters blood stream then organs
Recurrent invasion
Enteric fever
Severe type of enteric fever caused by Salmonella typhi
Typhoid fever
Typhoid fever is isolated in what specimen?
Blood (Wk 1-2)
Stool (Wk 2-3)
Urine (Wk 3-4)
Typhoid fever can be detected when the patient has previous infection through?
Vi or K antigen
What is the Incubation time of Salmonella enterica subspp. typhi?
9-14 days
What is the 1st week of infection for Typhoid fever?
Bacteremia
Ingestion in the mouth then enter blood stream
In the 2nd week of typhoid fever, where does the S. typhi penetrate to what system?
Reticuloendothelial system
What are the organs of Reticuloendothelial system?
Liver (Foci of necrosis)
Spleen
Bone marrow
What happen if S. typhi infects spleen?
Splenomegaly
What happens in 2nd and 3rd week of S. typhi
Involves in different organs
Process in 2nd to third week of S. typhi
Leave from RES then goes back to Lymphatic circulation then invades GIT
What happens if S. typhi invades GIT?
causes rash around the umbilical cord called rose spot
Intestinal bleeding / Ulceration (Peyer’s patches)
What happens in 3rd week of infection of Salmonella typhi?
Goes back to intestine
What happens in 4th week of infection of Salmonella typhi?
Goes to gallbladder which may cause severe infection or in Carrier state
Chronic State and infection and may involve other parts of the body
What is being collected on the 1st week of S. typhi infection?
Blood
What is being collected on the 2nd-3rd week of S. typhi infection?
Stool
What is being collected on the 3rd - 4th week of S. typhi infection?
Urine
When will the patient with S. typi be in a Carrier state?
4th week
Other enteric fevers may caused by?
paratyphi
choleraesuis
Prolonged fever with intermittent bacteremia
Nontyphoid bacteremia
Nontyphoid bacteremia is associated with?
typhimurium
paratyphi
choleraesuisy
What is the indication for 3rd to 4th week for Typhoid fever?
Rose spots
