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COB Molecular > 2.9 Intracellular Vesicular Trafficking 2 > Flashcards

2.9 Intracellular Vesicular Trafficking 2 Flashcards

1
Q

What happens in the R ER?

A

Ribosomes feed proteins through the Sec61 translocator

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2
Q

What happens in the R ER lumen?

A

Proteins are folded and gain sugar

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3
Q

Why is the S ER smooth?

A

Lacks ribosome association

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4
Q

What happens in the S ER?

A

Where vesicles bud from when cargo needs to go to the golgi

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5
Q

What happens in the S ER lumen?

A

Lipids gain sugar

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6
Q

What happens to folded and misfolded proteins that want to leave the ER?

A

Misfolded proteins go to the cytosol for degradation. Folded proteins go to the golgi for sorting.

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7
Q

Misfolded proteins go to the cytosol to be degraded via what?

A

Translocator

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8
Q

Folded proteins go to the Golgi for sorting via what?

A

Vesicles.

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9
Q

What proteins would return to the ER? For what Reason?

A

Rabs, SNAREs and cargo receptors must all go back for recycling.

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10
Q

What is the sorting seq for Rabs,SNAREs and cargo receptors?

A

KK??

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11
Q

What is the sorting seq for ER lumen resident proteins?

A

KDEL

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12
Q

What is homotypic fusion?

A

Many vesicles uncoat and duze with other vesicles. Forming these clusters.

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13
Q

Going from the ER to the Golgi, what part of the golgi is reached first?

A

Cis then the trans.

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14
Q

What part of the golgi goes to a lysosome?

A

Trans

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15
Q

What is autophagy?

A

Digestion of organelles by the lysosome

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16
Q

What are the 3 types of Endocytosis?

A

Receptor mediated, Phagocytosis, and pinocytosis

17
Q

Pertaining to receptor mediated endocytosis, what coat does it use? Budding?

A

Clathrin, and Actin.

18
Q

Pertaining to receptor mediated endocytosis, what is the cargo selection and cargo?

A

Receptor and cargo is specific to receptor

19
Q

Pertaining to receptor mediated endocytosis, what is a good example?

A

Cholesterol uptake

20
Q

Pertaining to phagocytosis, what is the coat and budding?

A

No coat. Budding is pseudopod

21
Q

Pertaining to phagocytosis, what is the cargo selection and cargo?

A

Antibody and the cargo is whole cell/large molecules

22
Q

Pertaining to phagocytosis, what is a good example?

A

Antigen presentation

23
Q

Pertaining to pinocytosis, what are the 3 coats used with their select buddings?

A
  1. Clathrin:amphi+Actin. 2. Claveolin: lipid composition. 3. No coat: actin.
24
Q

Pertaining to pinocytosis, what is the cargo selection and cargo?

A

Not selective and usually bulk fluid and small molecules.

25
Q

Pertaining to pinocytosis, what are the kinetics for the 3 coats?

A

Clathrin: fast. Claveolin:Slow. No coat: induced.

26
Q

Once inside the cell what happens to vesicles?

A

Vesicle will fuse into an endosome, they mature to get to a lysosome. (Not dealing with coats.)

27
Q

What is the Early endosome? What does it contain?

A

Also called sorting endosome. Has Rab5.

28
Q

What is the EE mediated by?

A

ESCRT

29
Q

What are some other functions of ESCRT?

A

Part of autophagy pathway, help remove protein coats, helps with budding viruses, exosome formation, and bridging between cells

30
Q

What does the recycling endosome (RE) contain?

A

Rab11

31
Q

What does the late endosome (LE) contain?

A

Rab 7

32
Q

What are the 3 possible fates of vesicles leave the trans golgi?

A
  1. Lysosome. 2/3 basically exocytosis.
33
Q

What coat do all vesicles that leave the golgi get?

A

Clathrin coat

34
Q

What happens if the lysosomes arnt working well?

A

Inability to break down whats inside the lysosome. Resulting in release (exocytosis) of these micro vesicles (little exosomes).

35
Q

What are some clinical implications if the lysosomes dont work well? What are some example of these diseases?

A

Neurodegenerative diseases. Alzheimers.

COB Molecular (36 decks)

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