2.12 extracellular matrix. Wound healing

Question 1

Epithelial tissue cells are connected by what?

Answer 1

cell to cell junction and have a limited ECM

Question 2

What is the ECM?

Answer 2

the basal lamina/basement membrane

Question 3

Where are the epithelial tissue cells?

Answer 3

outer layer, like the skin (epidermis) or lining of gut

Question 4

Connective tissue cells are connect by what?

Answer 4

Through extensive ECM and few cell to cell junctions

Question 5

Pertaining to Connective tissue cells, the fibroblasts secrete what?

Answer 5

the ECM

Question 6

Where are Connective tissue cells usually located?

Answer 6

Internal structures like bone and tendon

Question 7

What 2 roles does the ECM do?

Answer 7

Maintain tissue shape/structure, transmit signals.

Question 8

What are integrins?

Answer 8

Anchor the ECM to the cell membrane and interact with the cells cytoskeleton

Question 9

What do hemidesmosomes do?

Answer 9

Anchors intermediate filaments in a cell to extracellular matrix

Question 10

What do actin linked cell matrix junctions do?

Answer 10

Anchors actin filaments in cell to extracellular matrix.

Question 11

What are laminins?

Answer 11

Stay near the cell membrane and help cells stick together

Question 12

What is essentially the ECM?

Answer 12

A lattice of collagen fibers

Question 13

What is the structure of a collagen?

Answer 13

a triple helix = fibril (I, II. II)

Question 14

What collagen forms sheets?

Answer 14

IV

Question 15

What collagen cross the cell membrane?

Answer 15

XVII

Question 16

What collagen is the protein part of proteoglycans?

Answer 16

XVIII

Question 17

What collagen is associated with fibrils?

Answer 17

IX, XII

Question 18

What collagen make up mpre than 90% in the skin?

Answer 18

I, III

Question 19

What collagens are associated with Ethlers Danlos syndrome?

Answer 19

I, V.

Question 20

What are the clinical representation of Ethlers Danlos syndrome?

Answer 20

Extra flexibility.

Question 21

What collagen is associated with Alport Syndrome?

Answer 21

IV

Question 22

What is the clinical presentation of Alport syndrome?

Answer 22

Kidney failure, and hearing loss.

Question 23

What are proteoglycans?

Answer 23

Sugar modified peptides. Have more sugar than protein. They are huge.

Question 24

What are the 4 types of proteoglycans?

Answer 24

Decorin, Versican, Aggrecan, Syndecans

Question 25

What does Decorin do?

Answer 25

interacts with and regulated collagen fibers

Question 26

What does Versican do?

Answer 26

Interacts with elastins and influences cell migration

Question 27

Where are aggrecan found?

Answer 27

In cartilage

Question 28

What are syndecans? What do they interact with?

Answer 28

Transmembrane proteins that interact with actin

Question 29

What is a hyaluronan?

Answer 29

Sugar part of the proteoglycan.

Question 30

What are elastins?

Answer 30

flexible, interweaves with the collagen fibers in teh ECM. Crosslinked at lysine residues.

Question 31

What do fibronectins do?

Answer 31

Scaffold other ECM components together

Question 32

What is one weird thing about elastins?

Answer 32

Not glycosylated

Question 33

What are fibronectins?

Answer 33

More sugar with some protein.

Question 34

What is important for wound healing?

Answer 34

Scaffolding function in fibronectins

Question 35

What are MMPs important for?

Answer 35

Remodeling. Wounds.

Question 36

True or False? MMPs are turned off during would healing.

Answer 36

true

Question 37

What wounds do not leave scar tissue?

Answer 37

Fetal and oral wounds