Wk2 1.13-ECM: GaGs&PGs Flashcards
What are the three components of the extra cellular matrix? What is the MAIN component?
Proteins, PolySaccarides, and the MAIN component is Water
Now that we know the real general make up of the ECM, what more specifically makes it up? 4
Fibers, GlycoProteins, GlycosAminoGlycans, and ProteoGlycans
What is the stuff in the ECM that makes up the space between cells and fibers?
Ground Substance
What are the 3 components of Ground substance? What major player is NOT considered part of ground substance?
GlycoProteins, GlycosAminoGlycans, and ProteoGlycans (NO Fibers!)
What is the definine feature of connective tissue like bone, fat, blood, and cartilage.
Their extra cellular matrix! Lots of it in connective tissue!
What are the three MAIN macromolecules that make up the ECM? What is an example of each?
- PROTEO-GLYCANS (Glycos-Amino-Glycans) 2. FIBER (Collagen, Elastin) 3. MULTIADHESIVE PROTEINS
What are the four (plus one subcategory :)) major classes of GAG disaccharides?
1.Hyaluronan 2. Chondroitin Sufate 2a. Dermatin Suflate 3. HEP-AR-AN Sulfate 4. KeraTAN Sulfate (not keratin)
What is the general formula for GlycosAminoGlycan? (for the most part)
Amino Sugar + Carboxylic Sugar
What causes water to be sucked into the matrix and thus forming a gel?
Negative Charge of COO- and SO3- attracts Cations which then attracts lots of water into the matrix.
What is GAGs chief function?
maintain homeostasis
What is the formula for a PG (ProteoGlycan)?
GAG + ExtraCellularProtein = PG
What is the only GAG that does not form PG?
Hyaluronic Acid
What are the three classes of PGs? HOW AM I GOING TO REMEMBER THESE?!
1.Leucine Rich 2.Modular 3. Cell-Surface
What does a PG combine with to make PG Aggregates?
Hyaluronic Acid
What molecule acts as a biological shock absorber?
Hyaluronate
