3.3-Water Vitamins Flashcards
B1
Thiamine
B2
Riboflavin
B3
Niacin
B6
Pyridoxine
B9
Folic Acid
B12
Cobalamin
C
AS-COR-BIC Acid
B5
Pan-to-then-ic Acid
What is formed when we phosphorylate Thiamine (B1)? What 2 pathways is this involved in?
You get TPP! Thiamine PyroPhosphate…Pyruvate DeCarboxylase & PPP
What are the two possible syndromes of a prolonged B1 (Thiamine) deficiency?
Beri-Beri (muscle weakness, atrophy) & Wernike-Korsakoff Syndrome (dementia like, alcoholics)
What important molecule is Riboflavin (B2) converted to? Where is this intermediate used? What about a deficiency?
FAD+…Used for ETC!!, VERY rare to get a deficiency in B2 Riboflavin
What 2 important molecules is B3 (Niacin) converted to?
NAD+ and NADP
Which 2 water soluble vitamins can be made by bacteria? What AA does it start with for the first one? (Thanks Guys!!)
Niacin (B3)-start with tryptophan, Pyridoxine (B6)
What is the result of a Niacin (B3) deficiency? What are the three symptoms?
Pellagra: the 3 D’s: Dermatitis, Diarrhea, and Dementia (the fourth D is DEATH) :)
What important molecule is derived from Pantothenic Acid (B5). What can happen with a deficiency?
CoenzymeA- the very important molecule in making species reactive.. No known deficiency!
What important molecule is Pyridoxine (B6) converted to? What 2 functions does this molecule have?
Pyridoxal Phosphate–It helps in AA catabolism (aminotransferase) AND works with DALA to make HEME!
What is the important role of Biotin (B7)? What is the TIGHTEST BOND IN NATURE that can lead to a Biotin deficiency?
Fixation of CO2…Can become deficient when it binds to AVID-in. (an uncooked egg protein, have to consume like freaking 12 uncooked eggs to get a deficiency)
B7
Biotin
What important molecule is created from Folic Acid (B9)? What is the crazy outcome of a deficiency here?
TetraHydroFolate!! For 1 carbon metabolism… Megaloblastic Anemia
What are the 2 main structural features of Cobalamin (B12)?
1.Cobalt in the center and 2. 4 pyrrole rings surrounding it
What two processes need Cobalamin (B12)?
- Methionine Synthesis (SAM!!!) 2. Hematapoeisis (hey i founf it in beta oxidation too!!)
What are 2 results of Cobalamin (B12) deficiency?
1.Purine/Thymine synthesis 2. Pernicious Anemia (a type of megaloblastic anemia)
What are the two vitamin deficiencies that can lead to megaloblastic anemia?
Cobalamin (B12) and Folic Acid (B9) (makes sense because they are BOTH in the methyl cycle to make SAM!)
Which vitamin is a coenzyme in hydroxylation reactions?
As-cor-bic acid (Vitamin C), hydroxylate collagen fibers!
