1.14-ECMII-CollagenOnly

Question 1

What is the main function of collagen in the ECM?

Answer 1

STRUCTURE

Question 2

What cells synthesize collagen?

Answer 2

Fibroblasts

Question 3

What two AAs are really common in collagen?

Answer 3

Glycine and Proline

Question 4

Which collagen type is 90% of collagen in body?

Answer 4

Type I

Question 5

Which type of collagen is basement membrane?

Answer 5

Type IV

Question 6

Where is the bulk of collagen synthesis completed?

Answer 6

ER/Golgi

Question 7

How many Alpha chains come together to form the main collagen strand?

Answer 7

3, triple helix

Question 8

What is the collagen called after the strand has been released into the dock and the ends have been cleaved off?

Answer 8

TropoCollagen

Question 9

What molecule is important for the processing of collagen and if it goes wrong it causes scurvy? BOTH names please :)

Answer 9

Vitamin C aka ASCORBATE

Question 10

Is the extracellular cross linking of collagen covalent or ionic?

Answer 10

covalent

Question 11

Are Non-fibrilar collagens cleaved after secretion like fibrillar?

Answer 11

Nope

Question 12

What is the structure of collagen in tendons?

Answer 12

type I with type VI in middle

Question 13

What is the structure of collagen in cartilage?

Answer 13

type II w/ type IX on it

Question 14

What are the only two enzymes that can break down collagen?

Answer 14

Matrix metalloproteinases and cathepsins

Question 15

What is the type IV collagen disease we discussed?

Answer 15

Alport

Question 16

What is the Type I collagen disease we discussed?

Answer 16

Osteogenesis imperfecta

Question 17

What is the type III collagen disease we discussed? IN HISTO TOO!

Answer 17

Ehlers-Danlos