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Metabolism > 1.2-Membranes&Transport > Flashcards

1.2-Membranes&Transport Flashcards

1
Q

How thick is the phospholipid bilayer?

A

3 nanometers (you can fit 33,000 into a human hair) :) Marble to Earth analogy?!

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2
Q

What are the 3 MAJOR membrane lipid families?

A
  1. GlyceroPhosphoLipids 2. SphingoLipids 3. Cholesterol
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3
Q

What are the 3 major functions of cholesterol in the membrane?

A

Fluidity, Strength (only 3nm separating our DNA from the outside world), Shape

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4
Q

What is the odd type of PhosphoGlyceride that has an ether linkage instead of a esther linkage?

A

Plas-Mal-O-Gen

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5
Q

What are the four variable groups we talked about for GlyceroPhosphoLipids?

A
  1. EthanolAmide 2.Choline 3. Serine 4. In-O-Si-Tol
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6
Q

What is the intermediate between a TriAcylGlycerol and a GlyceroPhosphoLipid?

A

A PhosphidAte

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7
Q

What are the four types of sphingolipids?

A

1.CER-AMIDE 2. sphingo-MYELIN 3. Glucosyl-Cerebro-side 4. Ganglio-Side

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8
Q

What is the most common sphinolipid in our cells?

A

SphingoMyelin

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9
Q

What is the only sphingolipid AND phospholipid?

A

SphingoMyelin

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10
Q

What is the disease that arises from the inability to degrade gangliosides in the cell?

A

Tay-Sachs Disease (NERVOUS tissue most affected)

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11
Q

What is the disease that arises front he inability to degrade glucosyl-cerebro-sides?

A

Gaucher’s Disease

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12
Q

Is sphingoMyelin found more on the outer leaflet of the bilayer or the inner leaflet?

A

Outer

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13
Q

What are the two membrane liquids that form the “Lipid Raft”?

A

Cholesterol & SphingoMyelin

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14
Q

What are the two types of membrane protein?

A

Integral and Peripheral

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15
Q

Which membrane protein is embedded in two layers?

A

Integral

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16
Q

Which membrane protein is superficially attached to one side of the cell?

A

Peripheral

17
Q

About how many AA’s can fit into a membrane? FASCINATING

A

about 25

18
Q

Which integral membrane protein passes through the membrane one time? (very popular on RBCs)

A

Glyco-Phor-In

19
Q

What phenomena helps to anchor membrane proteins?

A

CHARGE! The negative charge of the phospholipid head is attracted to the positive portions of the protein to keep it anchored

20
Q

Which secondary AA structure is inside the membrane for the membrane protein?

A

Alpha-helix

21
Q

For a membrane protein like Glyco-Phor-In were are the carbohydrates found?

A

On the outside of the cell

22
Q

What were our two examples of Integral Membrane Proteins that pass through the cell more then once? How many times did they pass?

A

Rhodopsin (7) and Aquaporin (6)

23
Q

What are the three membrane protein anchors?

A

1.Acylation (Fatty Acyl Group + Glycene) 2. PREN-ylation (isoPRENE 5C group through Cystine) 3. GPI (Glycosly-Phosphatidyl-Inositol: contains P.I. & P.E.

24
Q

What are the three main types of protein transport?

A

Active, Facilitated, and Secondary Active

25
Q

What are the three types of secondary active transport?

A

Uniporters, Symporters, Antiporters

26
Q

What type of transport is Glucose taken into the cell by? What is the specific name of their membrane proteins?

A

Facilitated Transport. GLUTs

27
Q

How do the GLUTs get glucose into the cell?

A

Conformational change! Start open, accept the glucose, close, and open other side to let glucose in!

28
Q

What two drugs bind to Na/K pumps and block their activity?

A

Oua-Bain (Wee-baine) and Digoxin

29
Q

What are the four types of ATP powered transport proteins?

A
  1. P class (Plasma) 2. V class (Vacuolar) 3. F class (Fucking bacteria) 4. ABC Superfamily (AtpBindingCassett)
30
Q

How are the four types of ATP powered transport proteins grouped?

A

P,V,F all move ION against their [ ] gradients. ABD superfamily move molecules

Metabolism (35 decks)

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