Wk2 1.10-ETC Flashcards
What are the exchange rates for NADH and FADH2?
2.5ATP/ 1 NADH 1.5/ 1 FADH2
About how much volume do only mitochondria take in a liver cell? Cardiac cell?
Liver 20% Heart 50%
Do RBCs have mitochondria?
Nope
Which mitochondrial membrane has porins?
The outer mitochondrial membrane
Which ETC protein does not move H+’s across the inner mitochondrial membrane?
II
Which ETC protein receives NADH?
I
Which ETC protein receives FADH2?
II
Which two ETC proteins surround the Q pool?
II and III
What is the prosthetic group for the cytochrome ETC proteins? (III, IV)
Heme
What is the prosthetic group for ETC complex I?
FMN, a FAD relative (but I receives NADH anyway)
What is the prosthetic group for ETC complex II?
FAD
What happens to the reduction potential as we go down the ETC? Does it become more negative or more positive?
it becomes more positive. The more positive the more willing it is to accept electrons. O2 at the end has a huge reduction potential!
Whats the fancy scientific name for ETC complex I?
NADH-Q Oxidoreductase
Which ETC Complex is the home to seven ion clusters?
Complex I
Where do e’s get dropped off after going through the iron clusters in NADH-Q Oxidoreductase?
Ubiquinone (Coenzyme Q) (Q pool)
What is the fancy scientific name for ETC Complex II? What is the electron cab that flys into this terminal again?
Succinate DeHydrogenase…FADH2
What are the names for coenzyme Q when it is reduced and when it is not reduced?
Reduced: UbiqunOL (Its all fat happy and DRUNK with protons!!) Not reduced:Ubiquinone (both considered “coenzyme Q”)
What two complexes reduce ubiquinone to unbiquinol? Where do they drop off the reduced Ubiquinols?
Complexes I and II. They drop them off at Complex III
What is the “bottle neck” problem with the Q pool?
2e’s are coming in, but Cytochrome C can only carry one. so we bury one for the second half of the cycle
What is the scientific term for ETC Complex III?
Cytochrome bc1 complex
What class of molecules is characterized by an iron containing heme group bound to a protein?
Cytochromes
What is the scientific name for complex IV?
Cytochrome Oxidase
Which ETC complex has COPPER in it?!
IV
What two metal carriers (WITH their correct charge) pick up the electrons from cytocrome c at complex IV?
Cu2+ and Fe3+
What type of bond forms in between Fe and Cu in complex IV after they are reduced?
A peroxide bond!
What is the enzyme that protects or tissues from free oxygen radicals? THANK YOU!
SUPERMAN! (SuperOxide Dismutaste)
What is the metal in our superman enzyme that saves us from peroxide?
Mn (Manganese)
What are the two molecules that take save us from H2O2?
Catalase and Glutathione Peroxidase
Which step is blocked by CYANIDE and CO?
CytoChrome Oxidase (IV), blocks electron transport
How many degrees of rotation are needed to release a newly made ATP from ATP Synthase?
120 degrees
Which shuttle system exchanges and FADH2 for an NADH?
Glycerol-3-Phosphate Shuttle
Which shuttle moves NADH into the Matrix?
Malate Shuttle
Which ETC complex is the ONLY one without Fe-S as a prosthetic group?
IV Cytochrome Oxidase
