2.6 FattyAcid BioSynthesis Flashcards
What are the two major sites for FA Synthesis? What is the MAJOR site tho?
Liver and Mammary Gland! MAJOR MAJOR: Liver!
How many Acetyl CoAs, ATP, NADPH needed to make Palmitate?
8 AcetylCoA (2Cs each x 8=16 tot Cs), 7 ATP, 14 NADPH
Where does FA Synthesis occur?
The Cytosol
Which compound escorts Acetyl-CoA OUT of the Matrix to to make FAs in cytosol? What molecule enters the Matrix to keep this cycle going?
Citrate escorts it out, Pyruvate goes back in…VERY CONNECTED to Glycolysis
What is stage 1 in FA synthesis?
Formaiton of MAL-ON-YL CoA
What are the two building blocks for Malonyl CoA in stage 1?
AcetylCoA and Acetyl CoA Carboxylase
What happens in stage 2? What is the enzyme at work?
the FA chain elongates… Fatty Acid Synthase
What are the two necessary items for the conversion of Acetyl CoA to Malonyl CoA?
Biotin and CO2
What is the action that COMMITS the pathway to Fatty Acid Synthesis?
the Caboxylation of Acetyl-CoA to Malonyl-CoA
What does Glucagon do to FA Syn? Insulin?
Gulcagon=DONT MAKE FAT…Insulin=MAKE FAT
What molecule makes PROTOMERS assemble to make BIOTIN and therefore do FA Syn? Is the Biotin active without this?
CITRATE…Yes, just less active
How many domains are on Fatty Acid Synthase? (Step 2)
8!
What is the name of the “arm” of Fatty Acid Synthase in step 2?
PAN-TE-THE-INE Group
What are the 4 steps to FA Syn (opposite of B-Oxidation)?
Condensation, Reduction, Dehydration, Reduction
What two parts come together to make a 5C unit?
Acetyl CoA and MalonylCoA but you get4Cs after condensation
