Week 6 Anti-neoplastic drugs- Fitz

Question 1

What do you give to prevent hemorragic cystitis?

Answer 1

MESA (binds acroleint)

Question 2

What drugs need to be converted to active form in the liver?

Answer 2

Melphalan
Cyclophosphamide
Etoposide

Question 3

What are Melphalan/cyclophosphamide converted into?

Answer 3

Phosphoramide mustard (anti-neoplastic)
Acroleint (not active) - causes hemorragic cysitis

Question 4

Why is hydration important when taking melphalan/ cyclophosphamide?

Answer 4

Helps to dilute acroleint, and increase excretion

Question 5

Side affects of methotrexate?

Answer 5

bone marrow suppression

nephro and hepato toxicity

Question 6

What three things support methotrexate administration?

Answer 6

• hydration
• its a weak acid, will secret more if urine is alkalinated
• glucarpidase increases methotrexate degredation
• Leucoviorin- makes it so normal cells can bypass DHFR, rescue treatment for normal cells

Question 7

Leucoviorin

Answer 7

makes it so normal cells can bypass DHFR

rescue treatment for normal cells

Question 8

Arac-C

Answer 8

mimics ATP to block pyrimidine synthesis (treated acute myloid leukemia)

Question 9

Fludarabine

Answer 9

mimics ATP to block purine synthesis (treated acute myloid leukemia)

Question 10

Cyclophosphamide

Answer 10

alkylating agent that causes DNA crosslinking

• give with Mesna to bind acrolein
• NON SPECIFIC

Question 11

Cisplatin

Answer 11

platinus causes DNA crosslinking

-NON SPECIFIC

Question 12

Ifosfamide

Answer 12

alkylating agent that causes DNA crosslinking

-NON SPECIFIC

Question 13

Busulfan

Answer 13

alkylating agent that causes DNA crosslinking

-NON SPECIFIC

Question 14

glucarpidase

Answer 14

increases methotrexate degredation