Week 3 Case Study- Johns

Question 1

What do ET-A and ET-B target?

Answer 1

protein desmoglein- breaks apart a key protein to protein interacton that serves to hold together desmosome cells

Question 2

What does ET-A cause? What is it encoded by?

Answer 2

Bullous Impetigo

Encoded by lysogenized phage

Question 3

What does ET-B cause? What is it encoded by?

Answer 3

SSSS

Encoded by a plasmid

Question 4

SSSS vs. TEN?

Answer 4

TEN- separation of epidermis from dermis, older patients, sulfa drugs
SSSS- stratum granulosum from keratinocytes, young children, recent staph infections

Question 5

Differentiate between SSSS and pemphigus

Answer 5

Pemphigus punch biopsy reveal antibody to desmoglein

Question 6

Clinical presentations of a bad sore throat and rash? S. pyogenes vs. EBV?

Answer 6

S. pyogenes - causative agent of scarlet fever, ages 5-15

EBV- causes mono. Before 5 or young adults/teenagers

Question 7

Scarlet Fever

Answer 7

Group A Strep
Trunk rash
Red Tongue

Question 8

Kawasaki Disease

Answer 8

Autoimmune vasculitis
High fever, rash, red eyes, enlarged lymph nodes

No lab that helps

Question 9

SSSS

Treatment?

Answer 9

coagulase positive staph
ETB toxin
exfoliaton of skin
conjunctive reddness
fever
face and around mouth
Penicillinase-resistant penicillin