Week 4 NeuroCommunication- Fitz Flashcards

1
Q

Botulinum Toxin

A

destroy components of the docking apparatus that are required for vesicle fusion in neurons that utilize acetylchoine as a neurotransmitter: PREVENTING MUSCLE CONTRACTION

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2
Q

Tricyclin antidepressants, cocain, amphetamine, SSRIs

A

block re-uptake

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3
Q

Tetanus toxin

A
  • destroys the components of the docking apparatus, selectively in inhibitory neurons.
  • Toxin is transported retrogradely back across synapse
  • Taken up by synaptic terminals where it blocks release of INHIBITORY neurotransmitters
  • Motor neurons become OVERACTIVE
  • Spastic paralysis
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