Week 3 Derm Therapuetics- Evanson Flashcards
What provides the “bricks and mortar” barrier for the skin and is the rate-limiting step to topical therapy absorption?
Stratum corneum
What increase absorption by making the stratum corneum more penetrable?
hydration
What determines the level of occlusiveness and absorption?
The vehicle (cream vs. oinment)
What is an adverse affect of corticosteroids?
SKIN ATROPHY
What drug is a vitamin A analog?
Retinoids
What drug is a vitamin D analog?
Calcipotriene
Why do newer sunscreens work better against UVA?
They have avobenzone/helioplex or Mexoryl
What does SPF stand for? And which SPF blocks out 97% of the suns UV rays?
sun protection factor
SPF 30
MOA of Imiquidmod: Aldara cream
Immune response modifier
What does 5-FU inhibit?
thymidylate synthase
How should you care for a wound in general?
keep it covered with nonstick dressing to allow natural cytokines to facilitate healing
What does methotrexate inhibit? Major side effect?
Dihydrofolate reducatase inhibitor. Hepatotoxicity
Three stages of normal hair cycle?
Anagen to catagen to telogen
What is Telogen effluvium?
stress hair loss
What causes androgenetic alopecia?
genetically determined miniaturization of follicles trigged by androgens
What is alopecia areata?
Autoimmune, T-cells attack the hair bulb
What is secondary alopecia?
diffuse hair thinning as a complication of an existing medication or medical problem
How do you treat tinea capitis?
griseofulvin
Mechanism of Action of Retinoids?
Regulates cell growth, repairs disordered keratinization
Clicpotriene
vitamin D analog
alters skin differentiation
Use for psoriasis
Topical calcineruin
NSAID, alters T-cell activation
Use for eczema, dermatitis
Imiquidmod: Aldara cream
Increases immune system
Topical 5-fluorouracil
Thymidalate Synthase
Reduced DNA synthesis
For actinic keratosis
Dapsone
Use for neutrophilic skin diseases
Methotrexate
Side effect?
Dihydrofolate reducatse inhibitor
Side effect- hepatotoxicity
Biological Therapy
Biogenetically engineered proteins which disrupt/ inhibit focused portions of the immune system involved in psoriasis
UV Light Therapy
What do you use for?
Forms pyrimidine dimers in DNA and reduced langerhans cell and leukocytes. Anti-inflammatory and immunosuppressive
For psoriasis, pruritus, eczema
Minoxidil
Rogaine
Vasodilation and direct stimulation of hair shaft growth
alopecia
Finasterida
Blocks 5 alpha reductase enzyme in follicles to inhibit the conversion of testosterone to dihydrotestosterone
For androgenic alopecia
