Week 3 Derm Therapuetics- Evanson

Question 1

What provides the “bricks and mortar” barrier for the skin and is the rate-limiting step to topical therapy absorption?

Answer 1

Stratum corneum

Question 2

What increase absorption by making the stratum corneum more penetrable?

Answer 2

hydration

Question 3

What determines the level of occlusiveness and absorption?

Answer 3

The vehicle (cream vs. oinment)

Question 4

What is an adverse affect of corticosteroids?

Answer 4

SKIN ATROPHY

Question 5

What drug is a vitamin A analog?

Answer 5

Retinoids

Question 6

What drug is a vitamin D analog?

Answer 6

Calcipotriene

Question 7

Why do newer sunscreens work better against UVA?

Answer 7

They have avobenzone/helioplex or Mexoryl

Question 8

What does SPF stand for? And which SPF blocks out 97% of the suns UV rays?

Answer 8

sun protection factor

SPF 30

Question 9

MOA of Imiquidmod: Aldara cream

Answer 9

Immune response modifier

Question 10

What does 5-FU inhibit?

Answer 10

thymidylate synthase

Question 11

How should you care for a wound in general?

Answer 11

keep it covered with nonstick dressing to allow natural cytokines to facilitate healing

Question 12

What does methotrexate inhibit? Major side effect?

Answer 12

Dihydrofolate reducatase inhibitor. Hepatotoxicity

Question 13

Three stages of normal hair cycle?

Answer 13

Anagen to catagen to telogen

Question 14

What is Telogen effluvium?

Answer 14

stress hair loss

Question 15

What causes androgenetic alopecia?

Answer 15

genetically determined miniaturization of follicles trigged by androgens

Question 16

What is alopecia areata?

Answer 16

Autoimmune, T-cells attack the hair bulb

Question 17

What is secondary alopecia?

Answer 17

diffuse hair thinning as a complication of an existing medication or medical problem

Question 18

How do you treat tinea capitis?

Answer 18

griseofulvin

Question 19

Mechanism of Action of Retinoids?

Answer 19

Regulates cell growth, repairs disordered keratinization

Question 20

Clicpotriene

Answer 20

vitamin D analog
alters skin differentiation
Use for psoriasis

Question 21

Topical calcineruin

Answer 21

NSAID, alters T-cell activation

Use for eczema, dermatitis

Question 22

Imiquidmod: Aldara cream

Answer 22

Increases immune system

Question 23

Topical 5-fluorouracil

Answer 23

Thymidalate Synthase
Reduced DNA synthesis
For actinic keratosis

Question 24

Dapsone

Answer 24

Use for neutrophilic skin diseases

Question 25

Methotrexate

Side effect?

Answer 25

Dihydrofolate reducatse inhibitor

Side effect- hepatotoxicity

Question 26

Biological Therapy

Answer 26

Biogenetically engineered proteins which disrupt/ inhibit focused portions of the immune system involved in psoriasis

Question 27

UV Light Therapy

What do you use for?

Answer 27

Forms pyrimidine dimers in DNA and reduced langerhans cell and leukocytes. Anti-inflammatory and immunosuppressive
For psoriasis, pruritus, eczema

Question 28

Minoxidil

Answer 28

Rogaine
Vasodilation and direct stimulation of hair shaft growth
alopecia

Question 29

Finasterida

Answer 29

Blocks 5 alpha reductase enzyme in follicles to inhibit the conversion of testosterone to dihydrotestosterone
For androgenic alopecia