Week 4 Soft-tissue tumors- Nelson

Question 1

Describe in one or two sentences the classification scheme for mesenchymal/ soft tissue tumors.

Answer 1

Soft-tissue tumors are classified by the types of tissue that they recapitulate or differentiate to, they be divided into benign and malignant (sarcoma) forms.

Question 2

Describe the typical pattern of spread of sarcomas when they metastasize

Answer 2

a. Benign soft-tissue tumors outnumber malignant soft-tissue tumors
b. Sarcomas are rare but deadly
c. Usually metastasize via hematogenous routes (to lung and bone)

Question 3

State the type of cell that gives rise to soft tissue tumors

Answer 3

mesenchymal cells

Question 4

Most common type of genetic abnormalitiy in soft tissue tumors?

Answer 4

Specific chromosomal abnormalities, usually translocations!

Question 5

Which imaging technique is most helpful in assessment of soft tissue tumors or extrememties?

Answer 5

MRI

Question 6

Lipoma

Answer 6

benign fatty tumor

Question 7

Liposarcoma

Answer 7

malignant fatty tumor

Question 8

Pseudosarcomatous proliferations

Answer 8

benign lesion following local trauma/ injury

Question 9

Superficial fibromatoses

Answer 9

benign fibroblastic proliferation involving fascia or aponeruoses

Question 10

Deep-seated fibromatoses

Answer 10

benign fibroblastic proliferation, but can reoccur

Question 11

Fibrosarcoma

Answer 11

malignant, sarcomatous tumors of fibroblasts

Question 12

Rhabdomyoma

Answer 12

benign tumor showing skeletal muscle differentiation

Question 13

Rhabdomyosarcoma

Answer 13

malignant tumor showing skeletal muscle differentiation

Question 14

Leimyoma

Answer 14

benign tumor showing smooth muscle differentiation

Question 15

Leiomyosarcoma

Answer 15

malignant tumor showing smooth muscle differentiation

Question 16

hemangioma

Answer 16

benign lesion of blood vessel

Question 17

lymphangioma

Answer 17

benign lesion of lympathics

Question 18

Angiosarcoma

Answer 18

malignant. Showing endothelial differentiation

Question 19

Hemangioendotheliomas

Answer 19

malignant vascular tumors

Question 20

Differences between NF1 and NF2

Answer 20

NF1: more common, mutation of chromosome 17 coding for neurofibromin (tumor suppressor)

NF2: less common, mutation of chromosome 22 coding merline (regulates membrane receptor signaling, tumor suppressor)