Week 5 Arachinodic Acid- Trachte Flashcards
What enzyme is most likely to release arachidonic acid from membrane?
Phospholipase A2
What molecule mediated inflammation? Pain, Fever, vasodilation, uterine contraction
Prostaglandin E2
What would cause mycoardial infarction?
Increase Thromboxane A2
Or decrease Prostacyclin which prevents platelet aggregation
COX 2 inhibitors would block synthesis of what molecule?
Prostacyclin - likely to cause myocardial infarction
Acetylsalicylic acid
(Asprin) Irreversible inhibitor of thromboxane synthanse. Does some inhibition of COX1 and COX2
- give to reduce MI or stroke (eliminate thrombosis)
Celecoxib
(Celebrex)
- COX2 specific inhibitor
- less gastric ulceration
- Suppressed prostacyclin synthesis
- Most COX2 inhibitors have been taken off market because they cause MIs
Acetaminophen
Blocks COXs in central nervous system
- not in periphery
- NOT ANTI-INFLAMMATORY
What molecule mediates many inflammatory effects of rheumatoid arthritis?
Prostaglandins
- treat with ibuprofen and NSAIDs
- but DO NOT HALT disease progression
How do corticosteroids work?
- transcriptional regulators
- Reduce number of WBC
- Reduces release of arachidonic acid from membrane
- Inhibits prostaglandin and leukotriene synthesis
Dexamethasone
Hydrocortisone
Methylprednisolone
Prednisone
Corticosteroids
What suppresses both prostaglandin and leukotriene synthesis?
Cortiocosteroids
What relieves arthritis symptoms by reversilby blocking prostaglandin synthesis?
ibuprofen (Cox inhibitor)
What relieves arthritis symptoms and reduceds risk of MI?
Acetylsalicylic acid (aspirin)
What relieves arthritis treatment with the least risk of gastric ulceration?
Celecoxib
