Week 2 AntiFungal Drugs- Purnuske

Question 1

Amphotericin B, Nystatin

Answer 1

Binds ergosterol creating holes in membrane

Kills yeast and mold
Resistance is rare
Binds to cholesteral and causes NEPHROTOXICITY
*can cross blood brain barrier

Question 2

“Azoles”
Fluconazole
Itraconazole
Ketoconazole

Answer 2

binds fungal p450 enzyme and prevents production of ergosterol.
Resistance- alter p450 enzyme
-may cause hepatotoxicity and nephrotoxicity
-AVOID WHEN PREGO
**Most widely used

Question 3

Terbinafine

Answer 3

blocks production of ergosterol by inhibits squalene epoxidase.

• kills dermatophytes
• resistance is rare
• drug interactions with Cyp 2D6

Question 4

Fluctosine (5-FC)

Answer 4

selectively taken up by fungi and converted to 5 fluorouracil in fungi. Interferes with DNA/RNA synthesis

• YEAST ONLY
• can lead to bone marrow suppresion
• TREAT W/ AMPHOTERICIN B

Question 5

Griseofulvin

Answer 5

• binds microtubules and inhibits sliding
• fungistatic for dermatophytes
• Resistance= change in B-tubulin, if patient isn’t complient may develop
• AVOID WHEN PREGO
• lipids increase oral absorption

Question 6

Caspofungin

Answer 6

cell wall inhibitor, blocks synthesis of glucan

• Fungicidal for candida
• Treats Candida albicans
• Resistance = change in glucan synthase gene
• may get fever or rash as site of injection
• Have to give through IV