Week 4 Gonorrhea Case Study- Johns/Diebel

Question 1

What causes gout? How do you diagnosis it?

Answer 1

uric acid crystals

joint aspiration, negative birefringement crystals

Question 2

What causes pseudo gout? How do you diagnosis it?

Answer 2

pryophosphate crystal depositon

joint aspiration, POSITIVE birefringement crystals

Question 3

What two organisms can cause septic arthritis?

Answer 3

Staph Aureus

Neisseria gonorrhoeae

Question 4

Two musculoskeletal syndromes from disseminated GC?

Answer 4

Arthritis-dermatits syndrome

Localized septic arthritis

Question 5

Describe N. gonorrhoeae

Answer 5

gram negative
diplococci
oxidase +
only glucose oxidizer

Question 6

What specialized virulence factors of N. gonorrhoeae

Answer 6

specialized pili
endotoxin
capsule
IgA protease

Question 7

What media does N. gonorrhoease grow on?

Answer 7

Thayer-Martin

-inhibits growth of a lot of other stuff cuz has a lot of antibiotics

Question 8

What do you treat N. gonorrhoea with?

Answer 8

3rd generation of cephalosporin: ceftriaxone (+ doxycycline for probable concurrent chlamydia infection)

Question 9

Clinic Presentation of gonorrhoea?

Answer 9

asymptomatic
septic arthritis
complications if untreated

Question 10

Pathology of N. Gonorrhoea

Answer 10

• pili attach to mucosal cells of the urethra and vagina
• evades mucosal IgA antibodies via IgA protease
• endocytosed by cells
• kills cilitaed cells
• cal also invade submucosa and enter bloodstream, where it can collect in synovial fluid causing septic arthritis