Vasculitis Flashcards
What soft tissue condition is Temporal arteritis (giant cell arteritis) associated with?
What are the typical symptoms and signs of Temporal arteritis?
Polymyalgia rheumatica
Temporal headache
Scalp tenderness
Jaw claudication
Prominent arteries with reduced pulsation
What is vasculitis?
inflammation of blood vessels
What are the two important causes of large vessel vasculitis?
Giant cell arteritis (GCA)
Takayasu arteritis (TA)
Takayasu arteritis tends to affect what patients?
female
under 40
asian
What arteries are commonly affected by Giant Cell Arteritis?
What patients are typically affected?
temporal arteries
patients over 50
What clinical signs are common in Large Vessel Arteritis?
Carotid artery bruit Difference in blood pressure of extremities Claudication Vessel tenderness Hypertension
Temporal arteritis (giant cell arteritis) can cause blindness. (T/F)
True
-due to ischaemia of the optic nerve
What is the treatment of Giant Cell Arteritis?
High does steroids (40-60mg Prednisolone)
Kawasaki disease is a ______ vessel vasculitis which can lead to aneurysm formation in ______ arteries.
medium vessel
coronary arteries
What medium vessel vasculits is associated with hepatitis B and affects skin, gut and kidneys.
Polyarteritis nodosa
Granulomatosis with polyangitis (GPA) is a small vessel vasculitis, which typically presents at age 35-55 years.
What organs are affected?
ENT
- saddle nose
- mouth ulcers
- sinusitis
- nose bleeds
- deafness
Lungs
-pulmonary infiltrates
and cavitating nodules on CXR
-cough and haemoptysis
Skin
- palpable purpuric rash
- ulcers
Kidneys
-necrotising glomerulonephritis (blood and protein in urine)
Nervous system
- peripheral neuropathy
- cranial nerve palsies (eye)
Eye
-uveitis, conjunctivitis
Eosinophilic Granulomatosis with Polyangitis (EGPA) is similar to Granulomatosis with Polyangitis (GPA). What features of GPA are present less in EGPA?
ENT symptoms
What respiratordy condition is often present in EGPA (eosinophilic granulomatosis with polangitis)?
Late onset asthma
Granulomatosis with Polyangitis (GPA) is associated with what antibodies?
cANCA
PR3
What antibodies are detected in EGPA (eosinophilic granulomatosis with polangitis)?
pANCA
MPO
