Connective tissue disease

Question 1

What are the three antibodies tested for in Antiphospholipid Antibody Syndrome?

Answer 1

anti-cardiolipin antibody
lupus anticaogulant
beta 2 glycoprotein

Question 2

Anti-phospholipid Antibody Syndrome is associated with _____ _____ and adverse _____ ______. Lifelong ______ is therefore required, as well as ________.

Answer 2

Arterial thrombosis
and adverse pregnancy outcomes

Lifelong anticoagulation (aspirin/heparin in pregnancy)

Hydroxychloroquine

Question 3

A chronic autoimmune inflammatory disorder characterised by diminished lacrimal and salivary gland function resulting in dryness of eyes, mouth describes…

Answer 3

Sjorgen’s Syndrome

Question 4

What patient group is most commonly affected by Sjorgen’s syndrome?

Answer 4

women in 50s and 60s

Question 5

What are the symptoms of Sjorgen’s syndrome?

Answer 5

Dry eyes, mouth
Vaginal dryness
Fatigue
Poor dentition

Question 6

How is Sjorgen’s diagnosed?

What is the treatment?

Answer 6

1. History
2. Antibodies:
   - Anti-Ro
   - Anti-La
3. Schirmer’s test (ocular dryness)
4. Hydroxychloroquine
5. Immunosupression (methotrexate)
6. Tear/saliva supplements

Question 7

What is the most common presentation of Systemic Sclerosis?

Answer 7

Raynaud’s syndrome
-narrowing of small peripheral arteries (hands)

Also: calcinosis, sclerodactylity, Interstitial lung disease, oesophageal dysmotility

Question 8

What autoantibodies are present in Systemic Sclerosis?

Answer 8

• Anti-centromere

- Anti-scl-70

Question 9

What are the CREST features of limited Systemic Sclerosis?

Answer 9

Calcinosis
Raynaud's
Esophageal dysmotility (reflux)
Sclerodactyly 
Telangiectasia

Question 10

What is Raynaud’s syndrome? How is it treated?

Answer 10

Narrowing of small peripheral arteries (hands)

CCBs, Viagra

Question 11

Antibodies in SLE?

Answer 11

ANA, Anti-dsDNA, Anti-Sm, Anti-Ro

Question 12

Antibodies in Sjorgen’s syndrome?

Answer 12

Anti-Ro, Anti-La

Question 13

Antibodies in Systemic Sclerosis?

Answer 13

Anti-centromere

Anti-scl-70

Question 14

Antibodies in mixed connective tissue disease?

Answer 14

Anti-RNP

Question 15

Antibodies in Polymyositis?

Answer 15

Anti-Jo-1

Question 16

Antibodies in Anti-Phospholipid syndrome?

Answer 16

Beta 2 glycoprotein
Anti-cardiolipin
Lupus anti-coagulant

Question 17

Livedo reticularis, a mottled purplish vascular pattern seen on the skin, is associated with ….

Answer 17

Antiphospholipid syndrome