MSK pathology Flashcards
Vasculitis typically affects veins (T/F)
False
-Arteries
What is Kawasaki disease?
Vasculitis resulting from anti-endothelial autoantibody production
Giant Cell Arteritis is likely an autoimmune disease. What are its pathophysiological features?
segmental disease with skip lesions
Giant cell Arteritis is treated with ______
corticosteroids
What is an important complication of Giant cell Arteritis?
Infarction /Ischaemia of the opthalmic artery - leads to blindness
Polyarteritis nodosa (type of vasculitis) should be treated with…
corticosteroids
What is the pathology of polyarteritis nodosa?
- ‘Rosary sign’ beads of anuerisms
- Fibrinoid necrosis of vessel wall
- Transmural necrotising inflammation
What is the most common cause of gout? What drugs cause it?
Failure of urate secretion.
Thiazide diuretics - limit urate excretion
Calcium pyrophosphate cyrstals cause…
pseudogout
What causes Paget’s disease? What’s the pathology?
Increased osteoclast activity - bone breakdown
Production of excess bone with abnormal architecture
What is osteomalacia?
Abnormal Vitamin D metabolism, which results in weakness of bones.
What is the appearance of osteolytic bone metastases on XR?
radiolucent
What is the appearance of osteosclerotic bone metastases on XR?
area of opacity
What are the common sources of bone metastases?
Lung
kidney
breast
prostate
