Pharmacology of arthritis Flashcards
What is the progression of painkillers prescription?
- non-opioid analgesic (aspirin, paracetamol)
- weak opioid (codeine)
- strong opioid (morphine)
List some side effects of NSAIDs:
- peptic ulceration
- asthma exacerbation
- Cardiovascular events risk
- renal impairment
What is the first line treatment for Rheumatoid Arthritis?
Methotrexate
What antibody is present in most (but not all) Rheumatoid Arthritis patients?
Anti-Cyclic Citrullinated Peptide (CCP) antibody
DMARDs (such as Methotrexate) are fast-acting, with effects seen within days of administration (T/F)
False
Weeks to months for effects to occur
~6 weeks for Methotrexate
Methotrexate should never be used in pregnancy (T/F)
True
-highly teratogenic
What potential cutaneous side effect can be induced by Sulfasalazine (DMARD for RA)?
Stevens-Johnson syndrome
-widespread red/purple rash
What is the first-line drug in Lupus?
Hydroxychloroquine
The DAS-28 score has to be above ____ to indicate Anti-TNF biologic therapy for RA.
DAS-28> 5.1
_______ and _______ are used in gout prophylaxis (reduces uriceamia). It is NOT used in acute exacerbations.
Allopurinol
Febuxostat
Allopurinol may interact with Azathiprine causing irreversible _____ _______ _______
bone marrow suppression
What are the side effects of steroids?
- loss of bone density
- contribute to diabetes development
- weight gain
- muscle wasting
What are the side effects of steroids?
- loss of bone density
- contribute to diabetes development
- weight gain
- muscle wasting
Sulfasalazine and Hydroxychloroquine are both DMARDs that are safe to use in pregnancy (T/F)
True
What risks are associated with the use of anti-TNF therapy (infliximab)?
TB reactivation
Skin cancer
