MSK histology Flashcards
Striated, unbrached, multinucleate, with nuclei at the fibre periphery are characteristics of ______ muscle.
skeletal
What is the epimysium?
connective tissue that surrounds the whole muscle
The connective tissue around a single fascicle is the _____, whereas the connective tissue around a single muscle fibre is the _____
fascicle - perimysium
muscle fibre - endomysium
A muscle fibre bundle bound by perimysium connective tissue describes…
a fascicle
Describe the levels of skeletal muscle organisation:
- sarcomere
- myofibril
- muscle fibre
- fascicle
- skeletal muscle
__ ______ represents the attachment point for myosin/thick filaments
M line
Slow contracting fibres that depend on oxidative metabolism, are abundant in mitochondria and myoglobin and produce low force are called…
Type I fibres
‘slow twitch’
Intermediate fibres, relatively fast contracting are…
Type IIA
‘fast oxidative fibres’
Fast contracting fibres depending on anaerobic metabolsim, have fewer mitochondria and less moglobin, fatigue easily and produce large force …
Type IIB fibres
‘fast glycolytic fibres’
Cartilage is highly vascularised (T/F)
False
Avascular
What cells are found in cartilage?
Chondrocytes
The lacuna is …
extracellular matrix occupied by chondrocytes
What are the components of the Extracellular Matrix in cartilage?
Water (75%)
Type II collagen
Proteoglycan aggregates
_____ bone is formed of a fine meshwork found in the epiphyses of bones.
Cancellous / trabecular
The outer dense shell is the ____ bone, found in the diaphysis.
cortical bone
Layers of insterstitial lamellae in the cortical bone change direction witch each layer, providing it with tensile strength (T/F).
yup
Haversian Canals contain the osteonal _____
artery, vein and nerves
Osteocytes in lacunae access resources via ____, which connect them to _____
projections (dendrites) which connect them to the blood vessels in Haversian canals
What is the function of osteoclasts?
Bone resorption -
‘destruction’
What is the function of osteoblasts?
bone formation
What is the type of weak bone initially laid down following fracture (or during development)?
Woven bone
What is an osteon?
cylidrical units with cortical bone composed of layers of collagen fibres, with a central Harvesian canal containing blood vessels and nerves
What eventually happens to Woven bone?
It becomes remodelled into lamellar bone by osteoclasts and osteobasts