Rheumatoid arthritis Flashcards
Inflammation in rheumatoid arthritis is strictly limited to joints (T/F)
False
Extra-articular structures are affected
-vessels-> CV disease
Rheumatoid arthritis mainly affects peripheral joints. It is more prevalent in men. (T/F)
True
False
-3X more common in women
What is the aetiology of Rheumatoid arthritis?
Idiopathic
-autoimmune disease
List some common triggers of RA:
tobacco
stress
infection
Joints that are lined by ______ are affected by rheumatoid arthritis.
synovium
RA does not affect the spine. (T/F)
False
First 2 joints C1/C2 are affected
-they are lined with synovium
What are the symptoms of RA?
- morning joint stiffness
- pain and swelling
- sparing of distal interphalangeal joints
What examination tests would be carried out for RA?
Compression test of matecarpophalyngeal and metatarsophalyngeal joints
-tender if affected
What autantibodies are involved in RA?
- Anti-CCP
2. Rheumatoid factor (IgM)
What imaging tests are used in RA?
X-rays
Ultrasound
MRI
Active disease is indicated if the DAS28 score is above _____
2.7
What is the management progression in RA?
1. Aspirin/NSAIDs + steroids DMARDs: 2. +Methotrexate 3. +Sulfasalazine 4. +Hydroxychloroquine 5. Leflunomide 6. Gold injections, Azathioprine, Penicillamine 7.Biologic agents
- Gradually withdraw treatment
What drug causes pneumonitis, an allergic reaction in the lungs?
Methotrexate
What infection may reactivate due to use of biologic agents which block TNF-alpha (infliximab)?
TB
Erosion of the odontoid peg of axis can result in _____-______ ______
atlanto-axial instability
