Vascular Pathology

Question 1

What organ isn’t involved in PAN? What antibody is usually positive?

Answer 1

• Lung

- P-ANCA

Question 2

Finding in pathology in acute stage and lesions of polyarteritis nodosa

Answer 2

Segmental necrotizing vasculitis ▶️ fibrinoid necrosis and neutrophils

Question 3

Fibrinoid necrosis, neutrophils, granulomas (giant multinucleated cells); and C-ANCA

Answer 3

Wegener granulomatosis

Question 4

Difference between goodpasture syndrome and wegener granulomatosis, differential diagnosis when hemoptisis and hematuria

Answer 4

• wegener: upper and lower respiratory tract and granulomas

- goodpasture: only lower respiratory tract (alveolar hemorrhage)

Question 5

Treatment of kawasaki disease

Answer 5

ASA, IgG

Question 6

Microscopic findings of malignant hypertension

Answer 6

• hyperplastic arteriolosclerosis

- fibrinoid necrosis of vessels walls (necrotizing arteriolitis)

Question 7

Microscopic findings of benign hypertension

Answer 7

Hyaline arteriolosclerosis

Question 8

Disease where segmental trombosing vasculitis extendes to contiguous veins and nerves

Answer 8

Buerger’s disease (tromboangiitis obliterans)

*rarely seen in others types of vasculitis