Amyloidosis

Question 1

Most common affection in systemic form of amyloidosis

Answer 1

Kidney - nephrotic syndrome and/or progressive renal failure
Heart - restrictive cardiomyopathy, arrhythmia, CHF

Question 2

Amyloid protein and fibrillary protein in primary amyloidosis. Associated with which conditions?

Answer 2

• AL
• kappa, lambda light chains of Ig
• plasma cell disorder, multiple myeloma

Question 3

Amyloid protein and fibrillary protein in secondary amyloidosis, what type of diseases can you see related with it?

Answer 3

• AA
• serum amyloid A (SAA)
• neoplasia and chronic inflammatory (SLE, RA, Chron, etc)

Question 4

Amyloid protein AA, fibrillary protein SAA, autosomic recessive, neutrophilic dysfunction, recurrent fever

Answer 4

Familial Mediterranean fever

Question 5

Amyloid protein and fibrillary protein in hemodialysis-associated amyloidosis (end stage Renal disease). Clinical presentation associated.

Answer 5

• ABeta2M
• Beta2-microglobulin
• carpal tunnel syndrome

Question 6

Type of amyloid protein and fibrillary protein in Alzheimer

Answer 6

• ABeta

- beta-amyloid precursor protein (BAPP)

Question 7

Amyloid protein and fibrillary protein in senile cardiac amyloidosis

Answer 7

• ATTR

- transthyretin (TTR) [wild-type normal protein]

Question 8

Amyloid and fibrillary protein deposition in heritable amyloidosis. How is the manifestation?

Answer 8

• “ATTR”
• mutated transthyretin (TTR)
• Familial amyloid polyneuropathies