Skin Pathology Flashcards
Mutation of CMM1 gene, autosomal dominant trait, what condition develops the individual?
Dysplastic nevus syndrome ▶️ multiple dysplastic nevi ▶️ ⬆️ risk of melanoma
Most common type of melanoma
Superficial spreading melanoma
Type of melanoma with the worst prognosis
Nodular melanoma
*vertical growth pattern
What is the Leser-Trélat sign, and its significance?
Sudden development of multiple lesions of seborrheic keratoses ▶️ underlying malignancy (paraneoplasic syndrome)
Which antigen is target in pemphigus? Site of formation of bulla
- IgG (net-like pattern deposits) against desmoglein 3 (desmosome)
- acantholysis intraepidermal
*flaccid blister, easily rupture
Autoimmune disorder leading subepidermal blister, tense bullae, hard to rupture? Antigen targeted
- bullous pemphigoid
- IgG (linear deposit) against bullous pemphigoid antigen 1 and 2 (hemidesmosome)
Which are the precursors for squamous cell carcinoma?
- actinic keratosis
- Bowen disease
Why do you find basal cell carcinoma in hair-bearing areas (as face) and not in free hair areas (as palm)?
Basal cell carcinoma arises from basal cells of hair follicles
