Inflammation Flashcards
Main features of leukocyte adhesion deficiency
- autosomal recessive
- deficiency of B2 integrin subunit (CD18)
- recurrent bacterial infection
- delay umbilical cord sloughing
Hypersegmented neutrophils (more than 5) are usually though to be pathognomonic or suggest
Megaloblastic anemias (folate or vitamin B12 deficiency)
Autosomal recessive condition characterized by neutropenia, neutrophils with giant granules (lysosomes), defect in chemotaxis and degranulation
Chediak-Higashi syndrome
*transfer of melanin is also interrupted ▶️ albino
X-linked or autosomal recessive, deficiency of NADPH oxidase, lack superoxide and peroxide, recurrent bacterial infections with catalase-positive organisms (S. aureus), nitroblue tetrazolium test negative
Chronic granulomatous disease
What infection characterizes the myeloperoxidase deficiency?
Candida
Mediators of pain
- Bradykinin
- PG E2
Mediators of fever
- IL-1, IL-6, TNF
- PG
Cells that degrade the hemoglobin within the red blood cells to form hemosiderin at hepatic sinusoids
Kuppfer cells
Eosinophil component that is toxic to parasites, antihelminthic properties, triggering histamine release from mast cells and basophils, and activating neutrophils and macrophages.
Major basic protein
Cause of leukocyte adhesion deficiency type 2
⬇️ Sialyl-Lewis x (leukocyte)
Cause of leukocyte adhesion deficiency type 1
⬇️ CD18 integrin subunit (leukocyte)
Molecule that mediate the diapedesis of the leukocyte during inflammation either in endothelial as in leukocyte
PECAM-1 (CD31)
Mediator that induces and maintains granuloma formation, for what is important to know that relationship?
TNF-Alfa from macrophages
Anti-TNF drugs may break granuloma ▶️ disseminate disease
*test for latent TB before initiate anti-TNF
