Liver Pathology Flashcards
Decreased bilirubin excretion due to a defect in the canalicular cationic transport protein. Distinctive finding in liver.
Dubin-Johnson syndrome
Black pigmentation of the liver
Inflammation and granulomatous destruction of intrahepatic bile ducts. Which laboratory study is related at 90% of cases?
Primary biliary cirrhosis Antimitochondrial autoantibodies (AMA)
Segmental inflammation and fibrosing destruction of intrahepatic and extrahepatic bile ducts. Finding in cholangiogram.
Primary sclerosing cholangitis
“Beaded appearance”
What produce the fibrosis in a cirrhotic liver?
Ito cell (hepatic stellate cell)
Which test do you use to evaluate coagulopathy due to liver disease?
Prothrombin time (PT)
Non-hepatitis viruses which may infect the liver
EBV - infectious mononucleosis
CMV
Herpes
Yellow fever
Diagnosis of hepatitis A
Symptoms + IgM anti-HAV
Diagnosis hepatitis C and D
C ▶️ symptoms + anti-HCV ELISA
D ▶️ anti-HDV ELISA
What markers do you expect positive on window phase infection by HBV?
Only IgM anti HBcAg
How do you differentiate between prior infection and immunization?
IgG anti HBcAg (IgG HBcAb) ▶️ just in prior infection
Only marker that you don’t expect to find in chronic infection
IgG anti HBsAg (IgG HBsAb)
*it confers protection
Microscopically which finding allow you differentiate between alcoholic hepatitis and viral hepatitis?
Mallory bodies and fatty changes ▶️ alcoholic hepatitis
Treatment of Wilson’s disease
Copper chelators (D-penicillamine)
Deficient variant of Pi gene? What disease does it cause?
PiS ▶️ mildly ⬇️ Alfa-1 AT
PiZ ▶️ markedly ⬇️ Alfa-1 AT
Liver tumor associated with oral contraceptives use
Hepatic adenoma
