Immunopathology

Question 1

Common cause of lupus-like syndrome with antihistone antibodies

Answer 1

Hydralazine, isoniazid, procainamide

Question 2

Which condition is associated with maternal anti-Ro antibodies?

Answer 2

Congenital complete heart block

Question 3

Microorganism associated with progressive multifocal leukoencephalopathy in AIDS patients

Answer 3

JC virus

Question 4

AIDS- defining diseases

Answer 4

• hairy leukoplakia (EBV)
• Kaposi sarcoma (HHV8)
• non-Hodgkin lymphoma, extranodal CNS lymphoma
• cervical cancer
• HIV-wasting syndrome
• AIDS neuropathy
• AIDS dementia complex

Question 5

Based of modes of inheritance, which are the mutations and deficiencies associated with severe combined immunodeficiency (SCID)?

Answer 5

• X-linked recessive: common gamma chain of CK’s receptor ▶️ IL-2, 4, 7, 9, 15, 21.
• autosomal recessive: adenosine deaminase (ADA) deficiency

Question 6

Mutation in X-linked agammaglobulinemia of Bruton

Answer 6

B-cell Bruton tyrosine kinase (btk)