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Microbiology > Vaccines & Vaccine-Preventable Disease > Flashcards

Vaccines & Vaccine-Preventable Disease Flashcards

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Biology 101 flashcards
1
Q

bordetella pertusiss

A

whole cell vaccine

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2
Q

The pathogen has villains factors to destroy the action of respiratory cilia. What pathogen is this?

A

bordetella pertusiss

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3
Q

toxins cause inflammation that interferes with clearance of pulmonary secretion. what virus?

A

bordetella pertussis

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4
Q

What stage of pertussis involves the repetitive cough with whoops vomiting and leukocytosis?

A

paroxysomal stage

2-4 weeks

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5
Q

bordetella p. characterstics vaccine

A

Administered by intramuscular injection,
DTaP (Daptacel and Infanrix)
 Tdap (Adacel and Boostrix)
 DTaP-HepB-IPV (Pediarix)
 DTaP-IPV/Hib (Pentacel)
 DTaP-IPV (Kinrix and Quadracel)
 DTaP-IPV-Hib-HepB (Vaxelis)

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6
Q

what virus?

DTaP-HepB-IPV (Pediarix)
DTaP-IPV-Hib-HepB (Vaxelis)
HepA-HepB (Twinrix)

Contains antibiotics neomycin and polymyxin B, streptomycin

A

b. pertusiss

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7
Q

Inactivated (subunit) influenza vaccine (IIV)

A
  • Administered by intramuscular (IM) injection
  • Multidose vials contain thimerosal, some products contain residual egg protein

hib: influenza

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8
Q

Live, attenuated influenza vaccine (LAIV)

A
  • Vaccine viruses are grown in chicken eggs
  •  Administered intranasally (IN)
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9
Q

Recombinant influenza vaccine (RIV)

A
  • Contains recombinant hemagglutinin proteins
  • Does not require an egg-grown vaccine virus
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10
Q

HBV characteristics

A

recombinant vaccine (HBsAg)
*  Contain yeast protein
*  Administered by intramuscular injection
*  Contain aluminum adjuvant (Engerix-B and Recombivax HB) or synthetic adjuvant (Heplisav-B)
*  Some contain latex
*  Ingredients in combination vaccines differ; all contain antibiotics

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11
Q

HPV Vaccines:

A
  •  9vHPV (Gardasil 9) is licensed and currently distributed in the U.S.
  •  Prevents HPV types 6, 11, 16, 18, 31, 33, 45, 52, 58
  •  4vHPV prevents HPV types 6, 11, 16, 18
  •  2vHPV prevents HPV types 16, 18
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12
Q

HPV Vaccine Characteristics:

A
  • Recombinant vaccine (L1 major capsid protein)
  •  9vHPV contains yeast protein
  •  L1 proteins self-assemble into virus-like particles (VLP)
  •  VLPs are noninfectious and nononcogenic
  •  Administer by IM injection
  •  9vHPV contains aluminum adjuvant
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13
Q

Hib Vaccines
Three conjugate (monovalent) vaccines

A
  • PRP-T (ActHIB)
  •  PRP-T (Hiberix)
  •  PRP-OMP (PedvaxHIB
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14
Q

Two combination vaccines containing Hib

A

DTaP-IPV/Hib (Pentacel)
 DTaP-IPV-Hib-HepB (Vaxelis)

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15
Q

Hib Vaccine Characteristics

A
  • PRP-T use a tetanus toxoid carrier protein
  •  PRP-OMP uses a meningococcal outer membrane
    protein
  •  Administered by intramuscular injection
  •  PRP-OMP doses contain aluminum adjuvant
  •  Monovalent Hib vaccines contain no antibiotic or
    preservative
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16
Q

complication of H. influenza

A

bacterial meningitis

17
Q

clinical feature for c. diphtheriae

A

Produces an AB toxin that inhibits cellular protein synthesis, destroys local tissue, and forms a pseudomembrane
Aerobic or facultatively anaerobic Gram-positive irregularly shaped (“club-shaped”) rods
 Non-spore forming
 Contain short-chain mycolic acids but NOT acid-fast

18
Q

complications for c. diphtheriae

A

myocarditis, polyneuropathies, nephritis, and thrombocytopenia

19
Q

INACTIVATED VACCINES – TOXOID: E.G., C.DIPHTHERIAE

A

DT
 DTaP (Daptacel and Infanrix)
 Td (Tdvax and Tenivac)
 Tdap (Adacel and Boostrix)
 DTaP-HepB-IPV (Pediarix)
 DTaP-IPV/Hib (Pentacel)
 DTaP-IPV (Kinrix and Quadracel)
 DTaP-IPV-Hib-HepB (Vaxelis

20
Q

Human coronavirus infects and kills epithelial
cells of the upper respiratory tract.

A

ssRNA+, non-segmented, enveloped

21
Q

INACTIVATED VACCINES – NUCLEIC ACID: E.G., SARS-COV-2

A

mRNA vaccines
 Moderna COVID-19 Vaccine/SPIKEVAX (1) and Moderna COVID-19 Vaccine, Bivalent
 Pfizer-BioNTech COVID-19 Vaccine/COMIRNATY (2) and Pfizer-BioNTech COVID-19 Vaccine, Bivalent
 Protein subunit vaccine
 Novavax COVID-19 Vaccine, Adjuvanted
 Adenovirus vector vaccine
 Janssen (Johnson & Johnson) COVID-19 Vaccine

22
Q

what is inside smallpox vaccine?

A

vaccinia

23
Q

DTaP-HepB-IPV

A

hbv

24
Q

DTaP-IPV-Hib-HepB

A

Vaccine for h. influenzae

25
Q

mmr

A

measles,mupms, rabies

26
Q
A

Microbiology (21 decks)

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