Vaccines & Vaccine-Preventable Disease Flashcards
bordetella pertusiss
whole cell vaccine
The pathogen has villains factors to destroy the action of respiratory cilia. What pathogen is this?
bordetella pertusiss
toxins cause inflammation that interferes with clearance of pulmonary secretion. what virus?
bordetella pertussis
What stage of pertussis involves the repetitive cough with whoops vomiting and leukocytosis?
paroxysomal stage
2-4 weeks
bordetella p. characterstics vaccine
Administered by intramuscular injection,
DTaP (Daptacel and Infanrix)
Tdap (Adacel and Boostrix)
DTaP-HepB-IPV (Pediarix)
DTaP-IPV/Hib (Pentacel)
DTaP-IPV (Kinrix and Quadracel)
DTaP-IPV-Hib-HepB (Vaxelis)
what virus?
DTaP-HepB-IPV (Pediarix)
DTaP-IPV-Hib-HepB (Vaxelis)
HepA-HepB (Twinrix)
Contains antibiotics neomycin and polymyxin B, streptomycin
b. pertusiss
Inactivated (subunit) influenza vaccine (IIV)
- Administered by intramuscular (IM) injection
- Multidose vials contain thimerosal, some products contain residual egg protein
hib: influenza
Live, attenuated influenza vaccine (LAIV)
- Vaccine viruses are grown in chicken eggs
- Administered intranasally (IN)
Recombinant influenza vaccine (RIV)
- Contains recombinant hemagglutinin proteins
- Does not require an egg-grown vaccine virus
HBV characteristics
recombinant vaccine (HBsAg)
* Contain yeast protein
* Administered by intramuscular injection
* Contain aluminum adjuvant (Engerix-B and Recombivax HB) or synthetic adjuvant (Heplisav-B)
* Some contain latex
* Ingredients in combination vaccines differ; all contain antibiotics
HPV Vaccines:
- 9vHPV (Gardasil 9) is licensed and currently distributed in the U.S.
- Prevents HPV types 6, 11, 16, 18, 31, 33, 45, 52, 58
- 4vHPV prevents HPV types 6, 11, 16, 18
- 2vHPV prevents HPV types 16, 18
HPV Vaccine Characteristics:
- Recombinant vaccine (L1 major capsid protein)
- 9vHPV contains yeast protein
- L1 proteins self-assemble into virus-like particles (VLP)
- VLPs are noninfectious and nononcogenic
- Administer by IM injection
- 9vHPV contains aluminum adjuvant
Hib Vaccines
Three conjugate (monovalent) vaccines
- PRP-T (ActHIB)
- PRP-T (Hiberix)
- PRP-OMP (PedvaxHIB
Two combination vaccines containing Hib
DTaP-IPV/Hib (Pentacel)
DTaP-IPV-Hib-HepB (Vaxelis)
Hib Vaccine Characteristics
- PRP-T use a tetanus toxoid carrier protein
- PRP-OMP uses a meningococcal outer membrane
protein - Administered by intramuscular injection
- PRP-OMP doses contain aluminum adjuvant
- Monovalent Hib vaccines contain no antibiotic or
preservative
complication of H. influenza
bacterial meningitis
clinical feature for c. diphtheriae
Produces an AB toxin that inhibits cellular protein synthesis, destroys local tissue, and forms a pseudomembrane
Aerobic or facultatively anaerobic Gram-positive irregularly shaped (“club-shaped”) rods
Non-spore forming
Contain short-chain mycolic acids but NOT acid-fast
complications for c. diphtheriae
myocarditis, polyneuropathies, nephritis, and thrombocytopenia
INACTIVATED VACCINES – TOXOID: E.G., C.DIPHTHERIAE
DT
DTaP (Daptacel and Infanrix)
Td (Tdvax and Tenivac)
Tdap (Adacel and Boostrix)
DTaP-HepB-IPV (Pediarix)
DTaP-IPV/Hib (Pentacel)
DTaP-IPV (Kinrix and Quadracel)
DTaP-IPV-Hib-HepB (Vaxelis
Human coronavirus infects and kills epithelial
cells of the upper respiratory tract.
ssRNA+, non-segmented, enveloped
INACTIVATED VACCINES – NUCLEIC ACID: E.G., SARS-COV-2
mRNA vaccines
Moderna COVID-19 Vaccine/SPIKEVAX (1) and Moderna COVID-19 Vaccine, Bivalent
Pfizer-BioNTech COVID-19 Vaccine/COMIRNATY (2) and Pfizer-BioNTech COVID-19 Vaccine, Bivalent
Protein subunit vaccine
Novavax COVID-19 Vaccine, Adjuvanted
Adenovirus vector vaccine
Janssen (Johnson & Johnson) COVID-19 Vaccine
what is inside smallpox vaccine?
vaccinia
DTaP-HepB-IPV
hbv
DTaP-IPV-Hib-HepB
Vaccine for h. influenzae
