Adaptive Immunity (Pp) part1 Flashcards
Notes from Chapter 1 to 3. Flashcards end on the role of MHC associated antigen on the adaptive immune flash cards
Function of Plasma Cells : IgA
secretion of IgA into breastmilk
What cell secretes antibodies?
Plasma Cell
Antibodies may be produced as?
SO 10
Identify the basic structural components of the TCR.
Antibodies ( immunoglobulins) may be produced as membrane receptors of B lymphocytes and as proteins secreted by antigen-stimulated B cells that have differentiated into antibody-secreting plasma cells
chapter 4
Lymphocytes:
B lymphocytes function?
Cells of the adaptive immune system
mediators of humoral immunity
Specific recognition of antigens and generation of adaptive immune responses:
Lymphocytes:
T lymphocytes function?
(immunity)
Cells of the adaptive immune system (pp)
mediators of cell-mediated immunity
Specific recognition of antigens and generation of adaptive immune responses:
antigen-presenting cells:
dendritic cells function?,
Cells of the adaptive immune system (pp)
initiation of T cell responses, stimulate adaptive immune responses
Capture of antigens for display to lymphocytes:
antigen-presenting cells:
macrophages function?
Cells of the adaptive immune system (pp)
effector phase of cell-mediated immunity
Capture of antigens for display to lymphocytes:
antigen-presenting cells:
follicular dendritic cells function?
Cells of the adaptive immune system (pp)
display of antigens to B lymphocytes in humoral immune responses
Capture of antigens for display to lymphocytes:
effector cells:
t lymphocytes function?
Cells of the adaptive immune system (pp)
activation of phagocytes, killing infected cells
Elimination of antigens:
effector cells:
macrophages function?
Cells of the adaptive immune system (pp)
phagocytosis and killing of microbes
Elimination of antigens:
effector cells:
granulocytes function?
Cells of the adaptive immune system (pp)
killing microbes
Elimination of antigens:
4 types of polymorphonuclear (granulocytes) ?
neutrophils, basophils, eosinophils, mast cells
refer to the intro to immune flashcards
B lymphocytes recognize soluble or microbial surface antigens and differentiate into antibody-secreting cells called
Classes of lymphocytes ( chapter 1, pp)
plasma cells
B lymphocyte effector function is to?
Classes of lymphocytes ( chapter 1, pp)
Neutralization of microbe, phagocytosis, complement activation
Helper T lymphocyte has 3 effector function, what are they?
Classes of lymphocytes ( chapter 1, pp)
Activation of macrophage (cell-mediated immunity) , inflammation, activation of B lymphocytes (humoral immunity)
Cytotoxic T lymphocyte (CTL) effector function is to?
Classes of lymphocytes ( chapter 1, pp)
Killing of infected cells
Regulatory lymphocyte effector function is to?
Classes of lymphocytes ( chapter 1, pp)
Suppression of immune response
Both helper Tcells and cytotoxic T lymphocytes recognize peptides derived from intracellular microbial proteins displayed on the cell surface by?
Classes of lymphocytes ( chapter 1, pp)
major histocompatibility complex (MHC) molecules
Helper Tcells recognize MHC II displayed on the surface of macrophages or other APC , and secrete _____ ? what do they do?
Classes of lymphocytes ( chapter 1, pp)
cytokines that stimulate different mechanisms of immunity and inflammation
Cytotoxic T lymphocytes recognize peptides displayed by any type of ____ ?
Classes of lymphocytes ( chapter 1, pp)
infected cell type (or tumor cell) and kill these cells.
Regulatory Tcells ____ the activation of other lymphocytes, especially of Tcells, and ____ autoimmunity.
Classes of lymphocytes ( chapter 1, pp)
limit, prevent
CD4+ helper T lymphocytes phenotypic markers
Major properties of the lymphocytes (CH. 1 pp)
CD3+
CD4+
CD8-
CD8+
cytotoxic T
lymphocytes phenotypic markers
Major properties of the lymphocytes (CH. 1 pp)
CD3+
CD4-
CD8+
Regulatory
T cells phenopytic markers?
Major properties of the lymphocytes (CH. 1 pp)
CD3+
CD4+
CD25+
FoxP3+
fox news at 3pm
B Cells phenotypic markers?
Major properties of the lymphocytes (CH. 1 pp)
Fc receptors class II MHC , CD19, CD 23
All lymphocytes arise from common lymphoid progenitor cells in the ?
Origin of lymphocytes ( chapter 1 PP)
bone marrow
B lymphocytes mature in the ?
Origin of lymphocytes ( chapter 1 PP)
bone marrow
T lymphocytes mature in the ?
Origin of lymphocytes ( chapter 1 PP)
thymus
Mature lymphocytes leave the generative lymphoid organs and enter the circulation and secondary (peripheral)lymphoid organs, which are the major sites of immune responses where lymphocytes encounter …
Origin of lymphocytes ( chapter 1 PP)
antigens and are activated
(like getting your first job and receiving your first paycheck)
Naive lymphocytes express receptors for antigens but _____ (do or do not ) perform the functions that are required to eliminate antigens
Stages in the life history of lymphocytes (ch 1)
do not perform the functions