Antivirals

Question 1

Drug target: attachment

Attachment, block with neutralizing antibodies to ?

Answer 1

viral attachment proteins

Question 2

antitoxins for botulism and diphtheria are with which drug target?

Answer 2

attachment

Question 3

Drug target: attachment

hyperimmune globulins for postexposure prophylaxis for what diseases?

Answer 3

Hepatits B Virus, rabies, tetanus, varicella

Question 4

what drug target blocks with receptor antagonists

Answer 4

Drug target: attachment

Question 5

Drug target: attachment

block with receptor antagonist means?

Answer 5

peptide or sugar analogs of the cell receptor or viral attachment protein

Question 6

compounds that bind to CCR5 on macrophages and some CD4 T-cells (HIV) is apart of what drug target?

Answer 6

Drug target: attachment

Question 7

nucleotide biosynthesis and mutation drug?

Answer 7

ribavirin

Question 8

mutation: why?

Answer 8

a reason its hard to make antivirals

Question 9

thymidine kinase( drug activation) drugs?

Answer 9

acyclovir and penciclovir

Question 10

neuraminidase drugs?

Answer 10

zanamivir, oseltamivir

Question 11

maraviroc

Answer 11

antagonist of the CCR5,

Question 12

DRUG TARGET: PENETRATION & UNCOATING

Docosanol what does it do?

Answer 12

Inhibits the fusion of enveloped viruses (HSV) , used topically

Question 13

DRUG TARGET: PENETRATION & UNCOATING

Enfuvirtide (Fuzeon) what does it do?

Answer 13

Inhibits HIV’s viral fusion protein gp41

Question 14

Inhibiting mRNA synthesis does not make for a good target for antiviral drugs, but drugs do exist. what drug?

Answer 14

DRUG TARGET: TRANSCRIPTION

Question 15

Sofosbuvir

DRUG TARGET: TRANSCRIPTION

Answer 15

Prodrug for a nucleoside analog

Question 16

what drug inhibits HCV RNA-dependent RNA polymerase
(NS5B)?

DRUG TARGET: TRANSCRIPTION

Answer 16

Sofosbuvir

Question 17

Ribavirin

Answer 17

Resembles riboguanosine and promotes hypermutation and inhibits nucleoside biosynthesis, mRNA capping, and other processes (cellular and viral) important to the replication of HCV

DRUG TARGET: TRANSCRIPTION

Question 18

what medication gets trap in erthocytes and causes hemolytic anemia?

Answer 18

Ribavirin

DRUG TARGET: TRANSCRIPTION

Question 19

Inhibits influenza A and B viral
polymerase
what drug does this?

Answer 19

Baloxavir marboxil

DRUG TARGET: TRANSCRIPTION

Question 20

Inhibits the cap snatching
endonuclease activity of the viral polymerase, what drug does this?

Answer 20

Baloxavir marboxil

DRUG TARGET: TRANSCRIPTION

Question 21

Type 1 interferons function?

Answer 21

Attachment of polyethylene glycol to
IFN-α (pegylated IFN-α) increases its potency

DRUG TARGET: TRANSCRIPTION

Question 22

what drug target is this?

Block viral replication by degrading viral and cellular mRNAs.
- Blocks ribosomal
assembly
- Treats HPV, HCV

Answer 22

Type 1 interferons

DRUG TARGET: TRANSCRIPTION

Question 23

immunomodulators target what?

Answer 23

drug target: transcription , interferons, imiquimod

DRUG TARGET: TRANSCRIPTION

Question 24

STAT1 deficiency

Answer 24

viral vaccines, respiratoy viruses, encephalitis (HSV), CMV Mycobacteria

DRUG TARGET: TRANSCRIPTION

Question 25

imiquimod

Answer 25

binds to toll-like receptors ## Footnote IMMUNOMODULATORS: INTERFERONS, IMIQUIMOD

Question 26

used to treat HPV, gential warts?

Answer 26

imiquimod and Type 1 interferons ## Footnote IMMUNOMODULATORS: INTERFERONS, IMIQUIMOD

Question 27

DRUG TARGET: GENOME REPLICATION

Answer 27

Most antiviral drugs are nucleoside analogs, which are compounds with modifications of the base, sugar, or both

Question 28

Before being used by the polymerase, the nucleoside analogs must be

Answer 28

phosphorylated to the triphosphate form by viral enzymes (e.g., HSV thymidine kinase), cellular enzymes, or both ## Footnote DRUG TARGET: GENOME REPLICATION

Question 29

in genome replication enzyme targets DNA-dependent DNA polymerase of the ?

Answer 29

herpesviruses (hsv) ## Footnote DRUG TARGET: GENOME REPLICATION

Question 30

in genome replication the enzyme target reverse transcriptase of

Answer 30

HIV and hepatitis B virus (HBV) ## Footnote DRUG TARGET: GENOME REPLICATION

Question 31

Nonnucleoside reverse transcriptase inhibitors (NNRTIs), HIV drugs are ?

Answer 31

HIV drugs: nevirapine, delavirdine ## Footnote DRUG TARGET: GENOME REPLICATION

Question 32

Polymerase inhibitors: phosphonoformic acid (foscarnet, PFA), phosphonoacetic acid (PAA), takes pkace in what drug target?

Answer 32

DRUG TARGET: GENOME REPLICATION ## Footnote DRUG TARGET: GENOME REPLICATION

Question 33

Inhibit posttranslational modification of proteins

Answer 33

Protease inhibitors ## Footnote DRUG TARGET: PROTEIN SYNTHESIS,VIRION ASSEMBLY & RELEASE

Question 34

# what virus does this treat? grazoprevir, glicaprevir, simeprevir

Answer 34

(HCV) ## Footnote DRUG TARGET: PROTEIN SYNTHESIS,VIRION ASSEMBLY & RELEASE

Question 35

# what virus does this treat? Saquinavir, ritonavir, and indinavir

Answer 35

HIV ## Footnote DRUG TARGET: PROTEIN SYNTHESIS,VIRION ASSEMBLY & RELEASE

Question 36

# what virus does this treat? Nirmatrelvir

Answer 36

SARS-CoV-2 ## Footnote DRUG TARGET: PROTEIN SYNTHESIS,VIRION ASSEMBLY & RELEASE

Question 37

elvitegravir, doltuegravir, BI-224436, what virus does it inhibit?

Answer 37

HIV, intergrase inhibitor ## Footnote Integrase inhibitors

Question 38

these drugs target the protease (NS3/4A), the NS5A protein, and the polymerase (NS5B). what virus?

Answer 38

HCV

Question 39

valacyclovir, treats what virus?

Answer 39

herpes