vaccines Flashcards
Killed vaccines-bacterin
antigenically intact can't replicate unable to induce disease Requires adjuvant inactivated-chemicals often need multiple doses
does modified live require adjuvant
no, it’s growing and dividing so doesn’t need it
Subunit vaccines- toxoid
does not contain entire intact organism
specific immunogenic structural antigens
requires adjuvant
marker vaccines
discriminates between vaccine and exposure titers
differentiating infected from vaccinated animals
needs appropriate diagnostic test
what are some manufacturing errors
immunosuppression
clinical disease
death
abortion
how might a vaccine not work
prior passive immunizationh immunosuppressed inadequate vaccine wrong organism given too late
Common incorrect administration
death of live vaccine
inappropriate route
vaccine reactions
hypersensitivity
neuro
foreign body reaction
heterologous vaccine
antigenically related to target agent
no adjuvant required
adapted to different host species