Complement Flashcards

1
Q

Alternate pathway

A

Activated by invading microorganisms

Immediate response to infection

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2
Q

How is Enzymatic cascade started

A

Conversion of an initial protein to an enzyme

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3
Q

What happens after complement activation

A

Direct killing of bacteria
Phagocytosis of bacteria
Inflammation

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4
Q

What Ig’s are used in the classical complement pathway

A

IgM

IgG

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5
Q

What is C1

A

Binding site that turns from inactive to active protein when binded to

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6
Q

What does activated C1 do

A

Cleaves C4 into C4a and C4b

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7
Q

What does C1 do to C2

A

Cleaves it into C2a and C2b

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8
Q

What does C4b do

A

binds to cell surface

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9
Q

What does C2b do

A

binds to C4b and makes C3 convertase

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10
Q

What does C3 convertase do

A

Cleaves C3 into C3a and C3b

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11
Q

What does C3b do

A

Binds to bacterial cell surface

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12
Q

What does C3b do

A

binds C5b

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13
Q

What does C5b do

A

binds C6 and C7

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14
Q

What does the C5,6,7 complement do

A

Brings in C8

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15
Q

What does the C5,6,7,8 complement do

A

brings in C9 which creates a huge hole in the bacterial surface causing lysis

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16
Q

What is the C9 core formation called

A

MAC

17
Q

What is sialic acid

A

Molecule on mammalian cell membranes that differentiates mammalian from bacterial cells

18
Q

What happens when C3b sticks to a mammalian cell

A

H and I factors recognize Sialic acid and inactivate C3b

19
Q

What happens in the alternate complemement path on a bacterial cell membrane

A

C3b brings in Bb

20
Q

What is functionally similar to C4b2b in the alternate path

A

C3bBb

21
Q

what is important about C3

A

C3 biggest and largest amount

22
Q

What would happen if an animal didn’t have C3

A

Get sick from bacteria easier

23
Q

Classical pathway

A

Activated by antigen-antibody complexes formed during adaptive immune responses
5-7 days