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Immunology > Review #1 > Flashcards

Review #1 Flashcards

1
Q

What’s an example of a pamp and PRR that recognize each other

A

LPS-PAMP

TLR4-PRR

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2
Q

Characteristics of immature DC

A

In tissue
increased MHC in the cytoplasm
a lot of Endocytosis to sample things

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3
Q

Characteristics of mature DC

A

secondary lymph tissues
Increased MHC on the surface
lower endocytosis because it switches from sampling to presenting
makes cytokines that cause fever and bring in macrophages
-IL-1
-INF-alpha

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4
Q

What changes an immature DC into a mature DC

A

activation caused by PAMP/PRR interaction

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5
Q

What does TNF-a do

A

Blood vessels leak- Edema

Increase blood supply-heat

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6
Q

What’s an example secondary lymph node

A

lymph node follicle

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7
Q

What happens in lymph node follicle

A

DC presents antigen in the context of MHC 2 to CD4 T cell receptor paratope. CD3 and CD4 recognizes another part of the MHC 2
B7 from the DC and CD28 from T cell communicate

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8
Q

What is polygenic

A

several MHC 1 and 2

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9
Q

What is codominance

A

All MHC are expressed

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10
Q

What happens to T cell CD4 after 1st and 2nd signal

A

activates and Differentiates between Th1 and Th2

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11
Q

What are some characteristics of T cells that are Th1

A 
Effector cell
CD8
Cytotoxic
Tcells
-perfomin
-granzyme
-MHC1
-ADCC
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12
Q

What are some characteristics of Th2 T cells

A 
Effector cells
B cells to Ab
-opsonization
-complex
- blocking
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13
Q

What cytokines go with Th1

A

IL-2

IFN-a

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14
Q

What cytokines go with Th2

A

IL-4
IL-5
IL-10

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15
Q

How is a B cell activated

A 
BCR sees antigen, CD 79
Antigen is phagolysosomed 
Antigen presented on MHC2 on surface
TCR and CD4 recognize antigen 
CD40L and CD40 along with IL-4 cause second signal
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16
Q

What do macrophages and B cells activate

A

Both activate daughter T cells

17
Q

What does activated B cell do

A

Divide
Mature
make Ab

18
Q

Where do B-cells mature

A

Bursa/bursa equiv(bone marrow)

Make receptor-no antigen involvement

19
Q

What happens in the variable region of antibody

A

Ag recognition

20
Q

What happens in the Fc region of antibody

A

Class switching

Leukocyte

21
Q

IgG recognizes

A

MC and eosinophils

22
Q

IgG recognizes

A

NK cells

CD8 CTX

23
Q

What does VDJ relate to

A

Heavy chain

24
Q

What does VJ relate to

A

Light chain

25
Q

What contributes to BCR diversity

A 
Alleles VDJ
Combinatorial VDJ
Sloppiness
Combinatoral HC
Somatic hypermutation
26
Q

What is different about somatic hypermutation

A

only in secondary lymphoid tissues

not in T cells

27
Q

What is allelic exclusion

A

Make a heavy chain, turns off other chromosome (excludes the second allele)

28
Q

What’s the difference in number of chances to make chains between heavy and light chain

A

Heavy chain has 2 chances

Light chain has 4

29
Q

What are PAMP

A

proteins on bacteria

Immunology (28 decks)

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