Review #1 Flashcards
What’s an example of a pamp and PRR that recognize each other
LPS-PAMP
TLR4-PRR
Characteristics of immature DC
In tissue
increased MHC in the cytoplasm
a lot of Endocytosis to sample things
Characteristics of mature DC
secondary lymph tissues
Increased MHC on the surface
lower endocytosis because it switches from sampling to presenting
makes cytokines that cause fever and bring in macrophages
-IL-1
-INF-alpha
What changes an immature DC into a mature DC
activation caused by PAMP/PRR interaction
What does TNF-a do
Blood vessels leak- Edema
Increase blood supply-heat
What’s an example secondary lymph node
lymph node follicle
What happens in lymph node follicle
DC presents antigen in the context of MHC 2 to CD4 T cell receptor paratope. CD3 and CD4 recognizes another part of the MHC 2
B7 from the DC and CD28 from T cell communicate
What is polygenic
several MHC 1 and 2
What is codominance
All MHC are expressed
What happens to T cell CD4 after 1st and 2nd signal
activates and Differentiates between Th1 and Th2
What are some characteristics of T cells that are Th1
Effector cell CD8 Cytotoxic Tcells -perfomin -granzyme -MHC1 -ADCC
What are some characteristics of Th2 T cells
Effector cells B cells to Ab -opsonization -complex - blocking
What cytokines go with Th1
IL-2
IFN-a
What cytokines go with Th2
IL-4
IL-5
IL-10
How is a B cell activated
BCR sees antigen, CD 79 Antigen is phagolysosomed Antigen presented on MHC2 on surface TCR and CD4 recognize antigen CD40L and CD40 along with IL-4 cause second signal
What do macrophages and B cells activate
Both activate daughter T cells
What does activated B cell do
Divide
Mature
make Ab
Where do B-cells mature
Bursa/bursa equiv(bone marrow)
Make receptor-no antigen involvement
What happens in the variable region of antibody
Ag recognition
What happens in the Fc region of antibody
Class switching
Leukocyte
IgG recognizes
MC and eosinophils
IgG recognizes
NK cells
CD8 CTX
What does VDJ relate to
Heavy chain
What does VJ relate to
Light chain
What contributes to BCR diversity
Alleles VDJ Combinatorial VDJ Sloppiness Combinatoral HC Somatic hypermutation
What is different about somatic hypermutation
only in secondary lymphoid tissues
not in T cells
What is allelic exclusion
Make a heavy chain, turns off other chromosome (excludes the second allele)
What’s the difference in number of chances to make chains between heavy and light chain
Heavy chain has 2 chances
Light chain has 4
What are PAMP
proteins on bacteria
