MHC B cells

Question 1

What is signaling initiated by

Answer 1

Cross linking of adjacent BCR by antigens

Question 2

What is B-cell signaling essential for

Answer 2

Proliferation and differentiation into Ig- secreting plasma cells

Question 3

Is a single B-cell sufficient for activation

Answer 3

No

Question 4

What receptors are cross-linked for Bcell signaling initiation

Answer 4

BCR and Fc receptor

Question 5

What’s the second signal to B cell

Answer 5

CD40-CD40L

Question 6

What is the first signal to the b cell

Answer 6

BCR cross-linking
Increased CD40 expression
Specific response

Question 7

Full steps for activation of T and B cells

Answer 7

1st signal to B cell- antigen on antigen receptor
Processing of antigen- Makes B7 which will become the 2nd signal to T cell
1st signal to T cell- B cell Presents antigen to T cell
2nd signal to B cell- T cell presents CD40L to B cell
T cell makes IL-4 which goes to the T cell

Question 8

What happens when B cell is activated

Answer 8

Divide, mature, produce antibody

Question 9

What are ITAMs

Answer 9

parts of proteins in intercellular domain, when they get together they create….something